{"doi":"10.1101/2024.08.07.24311637","title":"Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption","abstract":"INTRODUCTION: Clinical and genetic studies have implicated lipid dysfunction in Alzheimer Disease (AD) pathogenesis. However, lipid consumption at the individual-level does not vary greatly within most cohorts, and multiple lipids are rarely measured in any one study. METHODS: Mean country-level lipid intakes were compared to Age-Standardized Alzheimer-Disease-Incidence-Rates(ASAIR) in 183 countries across all inhabited continents. Penalized spline regression and multivariable-adjusted linear regression, including a lag between intake and incidence, were used to assess the relationships between five lipid intakes and ASAIR. Validation was conducted using longitudinal within-country changes between 1990 and 2019. RESULTS: ). ASAIR also increased with saturated-fat, trans-fat, and dietary-cholesterol up to a threshold. The association between Omega6-PUFA and ASAIR was confirmed using longitudinal intake changes. DISCUSSION: Decreasing Omega6-PUFA consumption on the country-level may have substantial benefits in reducing the country-level burden of AD.","journal":"medRxiv","year":2024,"id":501912,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8436,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":560402,"name":"Giuseppe Tosto","orcid":"0000-0001-7075-8245","position":1,"is_corresponding":false},{"id":1351745,"name":"Razaq O Durodoye","orcid":null,"position":2,"is_corresponding":false},{"id":1351746,"name":"Farid Rajabali","orcid":null,"position":3,"is_corresponding":false},{"id":42482,"name":"Rufus Akinyemi","orcid":"0000-0001-5286-428X","position":4,"is_corresponding":false},{"id":405036,"name":"Goldie S. Byrd","orcid":"0000-0003-1057-0261","position":5,"is_corresponding":false},{"id":261839,"name":"William S. Bush","orcid":"0000-0002-9729-6519","position":6,"is_corresponding":false},{"id":256051,"name":"Brian W. Kunkle","orcid":"0000-0002-9515-5157","position":7,"is_corresponding":false},{"id":355816,"name":"Christiane Reitz","orcid":"0000-0001-8757-7889","position":8,"is_corresponding":false},{"id":40758,"name":"Jeffery M. Vance","orcid":"0000-0003-3815-8199","position":9,"is_corresponding":false},{"id":580857,"name":"Margaret A Pericak‐Vance","orcid":null,"position":10,"is_corresponding":false},{"id":6896,"name":"Jonathan L. Haines","orcid":"0000-0002-4351-4728","position":11,"is_corresponding":false},{"id":48175,"name":"SCOTT M. WILLIAMS","orcid":"0000-0002-4835-9544","position":12,"is_corresponding":false},{"id":1351494,"name":"Timothy H Ciesielski","orcid":"0000-0002-5629-3514","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:10:19.647285Z","pmid":"39148832","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}