{"doi":"10.1101/2024.08.05.24311527","title":"Reduced Risk of Cardiovascular Diseases after Bariatric Surgery Based on the New PREVENT Equations","abstract":"Background: We applied the novel Predicting Risk of Cardiovascular Disease EVENTs (PREVENT) equations to evaluate cardiovascular-kidney-metabolic (CKM) health and estimated CVD risk, including heart failure (HF), after bariatric surgery. Methods: Among 7804 patients (20-79 years) undergoing bariatric surgery at Vanderbilt University Medical Center during 1999-2022, CVD risk factors at pre-surgery, 1-year, and 2-year post-surgery were extracted from electronic health records. The 10- and 30-year risks of total CVD, atherosclerotic CVD (ASCVD), coronary heart disease (CHD), stroke, and HF were estimated for patients without a history of CVD or its subtypes at each time point, using the social deprivation index-enhanced PREVENT equations. Paired t-tests or McNemar tests were used to compare pre- with post-surgery CKM health and CVD risk. Two-sample t-tests were used to compare CVD risk reduction between patient subgroups defined by age, sex, race, operation type, weight loss, and history of diabetes, hypertension, and dyslipidemia. Results: CKM health was significantly improved after surgery with lower systolic blood pressure, non-high-density-lipoprotein cholesterol (non-HDL), and diabetes prevalence, but higher HDL and estimated glomerular filtration rate (eGFR). The 10-year total CVD risk decreased from 6.51% at pre-surgery to 4.81% and 5.08% at 1- and 2-year post-surgery (relative reduction: 25.9% and 16.8%), respectively. Significant risk reductions were seen for all CVD subtypes (i.e., ASCVD, CHD, stroke, and HF), with the largest reduction for HF (relative reduction: 55.7% and 44.8% at 1- and 2-year post-surgery, respectively). Younger age, White race, >30% weight loss, diabetes history, and no dyslipidemia history were associated with greater HF risk reductions. Similar results were found for the 30-year risk estimates. Conclusions: Bariatric surgery significantly improves CKM health and reduces estimated CVD risk, particularly HF, by 45-56% within 1-2 years post-surgery. HF risk reduction may vary by patient's demographics, weight loss, and disease history, which warrants further research.","journal":"medRxiv","year":2024,"id":487248,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9383,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":747276,"name":"Xinmeng Zhang","orcid":"0000-0001-7876-0753","position":1,"is_corresponding":false},{"id":692041,"name":"You Chen","orcid":"0000-0001-8232-8840","position":2,"is_corresponding":false},{"id":338843,"name":"Charles R. Flynn","orcid":"0000-0002-3749-0598","position":3,"is_corresponding":false},{"id":338842,"name":"Wayne J. English","orcid":"0000-0001-9663-5761","position":4,"is_corresponding":false},{"id":409111,"name":"Jason M. Samuels","orcid":"0000-0001-5427-3117","position":5,"is_corresponding":false},{"id":1331220,"name":"Brandon Williams","orcid":"0000-0001-7599-6058","position":6,"is_corresponding":false},{"id":1239287,"name":"Matthew D. Spann","orcid":"0000-0001-9228-6656","position":7,"is_corresponding":false},{"id":386002,"name":"Vance L. Albaugh","orcid":"0000-0002-5267-8951","position":8,"is_corresponding":false},{"id":240065,"name":"Xiao‐Ou Shu","orcid":"0000-0002-0711-8314","position":9,"is_corresponding":false},{"id":299434,"name":"Danxia Yu","orcid":"0000-0002-1710-9382","position":10,"is_corresponding":false},{"id":796043,"name":"Lei Wang","orcid":"0000-0003-0734-7026","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:06.013846Z","pmid":"39148843","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}