{"doi":"10.1101/2024.08.01.24311290","title":"Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant <i>Enterococcus faecium</i>","abstract":"ABSTRACT Vancomycin-resistant Enterococcus faecium (VREfm) is a prevalent healthcare-acquired pathogen. Gastrointestinal colonization can lead to difficult-to-treat bloodstream infections with high mortality rates. Prior studies have investigated VREfm population structure within healthcare centers. However, little is known about how and why hospital-adapted VREfm populations change over time. We sequenced 710 healthcare-associated VREfm clinical isolates from 2017-2022 from a large tertiary care center as part of the Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT) program. Although the VREfm population in our center was polyclonal, 46% of isolates formed genetically related clusters, suggesting a high transmission rate. We compared our collection to 15,631 publicly available VREfm genomes spanning 20 years. Our findings describe a drastic shift in lineage replacement within nosocomial VREfm populations at both the local and global level. Functional and genomic analysis revealed, antimicrobial peptide, bacteriocin T8 may be a driving feature of strain emergence and persistence in the hospital setting. Summary This study shows local and global lineage replacement of vancomycin-resistant Enterococcus faecium . Bacteriocin T8 is enriched in emergent lineages and provides a strong competitive advantage in vitro and in vivo .","journal":"medRxiv","year":2024,"id":487246,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1072626,"name":"Alexander B. Smith","orcid":"0000-0001-5407-0141","position":1,"is_corresponding":false},{"id":356082,"name":"M. Patrick Griffith","orcid":"0000-0003-1012-881X","position":2,"is_corresponding":false},{"id":727101,"name":"Katharine Hewlett","orcid":"0009-0008-1311-5049","position":3,"is_corresponding":false},{"id":1046650,"name":"Lora Pless","orcid":"0000-0003-0163-3689","position":4,"is_corresponding":false},{"id":334726,"name":"Alexander Sundermann","orcid":"0000-0002-2439-6287","position":5,"is_corresponding":false},{"id":281657,"name":"Lee H. Harrison","orcid":"0000-0002-3787-2705","position":6,"is_corresponding":false},{"id":322994,"name":"Joseph P. Zackular","orcid":"0000-0002-3228-3055","position":7,"is_corresponding":false},{"id":302051,"name":"Daria Van Tyne","orcid":"0000-0001-7284-0103","position":8,"is_corresponding":false},{"id":859596,"name":"Emma G. Mills","orcid":null,"position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:06.013846Z","pmid":"39132485","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}