{"doi":"10.1101/2024.07.18.604163","title":"SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity Through B Cell Antigen Presentation","abstract":"ABSTRACT Current neoantigen cancer vaccines activate T cell immunity through dendritic cell /macrophage-mediated antigen presentation. It is unclear whether incorporating B cell-mediated antigen presentation into current neoantigen vaccines could enhance CD4/CD8 T cell immunity to improve their anticancer efficacy. We developed a SARS-CoV-2 B cell epitope-guided neoantigen peptide/mRNA cancer nanovaccines (B SARS T NeoAg Vax) to improve anticancer efficacy by enhancing tumor-specific CD4/CD8 T cell antitumor immunity through B cell-mediated antigen presentation. B SARS T NeoAg Vax crosslinked with B cell receptor, promoted SARS-CoV-2 B cell-mediated antigen presentation to tumor-specific CD4 T cells, increased tumor-specific follicular/non-follicular CD4 T cells, and enhanced B cell-dependent tumor-specific CD8 T cell immunity. B SARS T NeoAg Vax achieved superior efficacy in melanoma, pancreatic, and breast cancer models compared to the current neoantigen vaccines. Our study provides a universal platform, SARS-CoV-2 B epitope-guided neoantigen nanovaccines, to improve anticancer efficacy against various cancer types by enhancing CD4/CD8 T cell antitumor immunity through viral-specific B cell-mediated antigen presentation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":491459,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":388641,"name":"Shuai Mao","orcid":"0000-0003-0856-8007","position":1,"is_corresponding":false},{"id":1337406,"name":"Zera Montemayor","orcid":null,"position":2,"is_corresponding":false},{"id":1337407,"name":"Mohamed Dit Mady Traore","orcid":null,"position":3,"is_corresponding":false},{"id":1337408,"name":"Alejandra Duran","orcid":null,"position":4,"is_corresponding":false},{"id":1070496,"name":"Fang Ke","orcid":"0000-0001-8011-147X","position":5,"is_corresponding":false},{"id":1337409,"name":"Mahamadou Djibo","orcid":null,"position":6,"is_corresponding":false},{"id":1337410,"name":"Hanning Wen","orcid":null,"position":7,"is_corresponding":false},{"id":1337052,"name":"Wei Gao","orcid":"0000-0002-5840-3609","position":8,"is_corresponding":false},{"id":262031,"name":"Duxin Sun","orcid":"0000-0002-6406-2126","position":9,"is_corresponding":false},{"id":846355,"name":"Chengyi Li","orcid":"0000-0003-2378-6408","position":0,"is_corresponding":true}],"reference_count":103,"raw_metadata":null,"created_at":"2026-07-19T02:08:45.247225Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}