{"doi":"10.1101/2024.07.08.600416","title":"Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain","abstract":"Despite abundant evidence of functional networks in the human brain, their neuronal underpinnings, and relationships to real-time behavior have been challenging to resolve. Analyzing brain-wide intracranial-EEG recordings with video monitoring, acquired in awake subjects during clinical epilepsy evaluation, we discovered the tendency of each brain region to switch back and forth between 2 distinct power spectral densities (PSDs 2-55Hz). We further recognized that this 'spectral switching' occurs synchronously between distant sites, even between regions with differing baseline PSDs, revealing long-range functional networks that would be obscured in analysis of individual frequency bands. Moreover, the real-time PSD-switching dynamics of specific networks exhibited striking alignment with activities such as conversation and hand movements, revealing a multi-threaded functional network representation of concurrent naturalistic behaviors. Network structures and their relationships to behaviors were stable across days, but were altered during N3 sleep. Our results provide a new framework for understanding real-time, brain-wide neural-network dynamics.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":487185,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506238,"name":"Andrew J. Michalak","orcid":"0000-0002-7401-8364","position":1,"is_corresponding":false},{"id":395635,"name":"Edward M. Merricks","orcid":"0000-0001-8172-3152","position":2,"is_corresponding":false},{"id":1053110,"name":"Alexander HCW Agopyan-Miu","orcid":"0000-0003-1914-7857","position":3,"is_corresponding":false},{"id":240430,"name":"Joshua Jacobs","orcid":"0000-0003-1807-6882","position":4,"is_corresponding":false},{"id":797971,"name":"Marla J. Hamberger","orcid":"0000-0003-1076-4373","position":5,"is_corresponding":false},{"id":240427,"name":"Sameer A. Sheth","orcid":"0000-0001-8770-8965","position":6,"is_corresponding":false},{"id":49954,"name":"Guy M. McKhann","orcid":"0000-0002-9695-3564","position":7,"is_corresponding":false},{"id":270526,"name":"Neil A. Feldstein","orcid":"0009-0001-2352-1031","position":8,"is_corresponding":false},{"id":240429,"name":"Catherine A. Schevon","orcid":"0000-0002-4485-7933","position":9,"is_corresponding":false},{"id":44862,"name":"Elizabeth M. C. Hillman","orcid":"0000-0001-5511-1451","position":10,"is_corresponding":false},{"id":1331162,"name":"Hongkun Zhu","orcid":"0009-0007-2560-9639","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-19T02:08:06.013846Z","pmid":"39026706","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}