{"doi":"10.1101/2024.06.25.600651","title":"ClOneHORT: Approaches for Improved Fidelity in Generative Models of Synthetic Genomes","abstract":"Motivation: Deep generative models have the potential to overcome difficulties in sharing individual-level genomic data by producing synthetic genomes that preserve the genomic associations specific to a cohort while not violating the privacy of any individual cohort member. However, there is significant room for improvement in the fidelity and usability of existing synthetic genome approaches. Results: We demonstrate that when combined with plentiful data and with population-specific selection criteria, deep generative models can produce synthetic genomes and cohorts that closely model the original populations. Our methods improve fidelity in the site-frequency spectra and linkage disequilibrium decay and yield synthetic genomes that can be substituted in downstream local ancestry inference analysis, recreating results with .91 to .94 accuracy.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":491282,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":304235,"name":"Víctor Borda","orcid":"0000-0003-3209-3961","position":1,"is_corresponding":false},{"id":1194768,"name":"Shuo Chen","orcid":"0000-0003-1512-376X","position":2,"is_corresponding":false},{"id":11361,"name":"Kari E. North","orcid":"0000-0002-8903-0366","position":3,"is_corresponding":false},{"id":935411,"name":"Robert Kaplan","orcid":null,"position":4,"is_corresponding":false},{"id":91089,"name":"Timothy D. O’Connor","orcid":"0000-0002-0276-1896","position":5,"is_corresponding":false},{"id":1172542,"name":"Roland Laboulaye","orcid":"0000-0002-4740-6548","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:41.211111Z","pmid":"38979338","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}