{"doi":"10.1101/2024.06.14.598876","title":"DeMBA: a developmental atlas for navigating the mouse brain in space and time","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>Studies of the adult mouse brain have benefited from three-dimensional (3D) atlases providing standardised frameworks for data analysis and integration. However, few 3D atlases exist for the developing mouse brain, and none cover more than a few ages. This fails to represent the dynamic nature of development and is insufficient for researchers whose data fall between the ages of existent atlases. Existing atlases also neglect the spatial correspondence between ages, making comparison across ages difficult. We present the Developmental Mouse Brain Atlas (DeMBA), a 4D atlas encompassing every postnatal day from 4 to 56. DeMBA is incorporated in software for spatial registration and analysis, enabling brain-wide quantification of features of interest. Furthermore, we provide a software package, the CCF translator, allowing coordinates or image volumes to be transformed between ages for comparison. These resources provide age-specific spatial frameworks incorporated in accessible analytic pipelines for developmental mouse brain data.</jats:p>","journal":null,"year":null,"id":595460,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":35.2,"corpus_rank":8270,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":165613,"name":"Heidi Kleven","orcid":"0000-0002-3710-321X","position":1,"is_corresponding":false},{"id":1524392,"name":"Martin Øvsthus","orcid":"0000-0002-6175-1647","position":2,"is_corresponding":false},{"id":1524394,"name":"Sharon C. Yates","orcid":"0000-0002-3001-8725","position":3,"is_corresponding":false},{"id":1524396,"name":"Gergely Csucs","orcid":"0000-0002-2093-6274","position":4,"is_corresponding":false},{"id":986672,"name":"Maja Puchades","orcid":"0000-0002-4536-8197","position":5,"is_corresponding":false},{"id":1524397,"name":"Simon McMullan","orcid":"0000-0002-9854-1029","position":6,"is_corresponding":false},{"id":95898,"name":"Jan G. Bjaalie","orcid":"0000-0001-7899-906X","position":7,"is_corresponding":false},{"id":1357144,"name":"Trygve B. Leergaard","orcid":"0000-0001-5965-8470","position":8,"is_corresponding":false},{"id":1411770,"name":"Ingvild E. Bjerke","orcid":"0000-0002-2926-6836","position":9,"is_corresponding":false},{"id":1524390,"name":"Harry Carey","orcid":"0000-0002-4111-6259","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DeMBA: a developmental atlas for navigating the mouse brain in space and time","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>Studies of the adult mouse brain have benefited from three-dimensional (3D) atlases providing standardised frameworks for data analysis and integration. However, few 3D atlases exist for the developing mouse brain, and none cover more than a few ages. This fails to represent the dynamic nature of development and is insufficient for researchers whose data fall between the ages of existent atlases. Existing atlases also neglect the spatial correspondence between ages, making comparison across ages difficult. We present the Developmental Mouse Brain Atlas (DeMBA), a 4D atlas encompassing every postnatal day from 4 to 56. DeMBA is incorporated in software for spatial registration and analysis, enabling brain-wide quantification of features of interest. Furthermore, we provide a software package, the CCF translator, allowing coordinates or image volumes to be transformed between ages for comparison. These resources provide age-specific spatial frameworks incorporated in accessible analytic pipelines for developmental mouse brain data.</jats:p>","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W4399709361","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"945539","title":"Human Brain Project Specific Grant Agreement 3"},{"funder_name":"European Commission","grant_id":"101147319","title":"EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2024/06/14/2024.06.14.598876.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2024/06/14/2024.06.14.598876.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2024.06.14.598876","host_type":"publisher"},{"url":"https://doi.org/10.1101/2024.06.14.598876","host_type":"repository"},{"url":"https://doi.org/10.1038/s41467-025-63177-9","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/40883284","host_type":""},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12397216/","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/40883284/","host_type":""},{"url":"http://dx.doi.org/10.1101/2024.06.14.598876","host_type":""}],"fields_of_study":["Health, Environment, Cognitive Aging"],"mesh_terms":[],"keywords":["Atlas (anatomy)","Space (punctuation)","Cartography","Neuroscience","Cognitive science","Geography","Psychology","Computer science","Biology","Anatomy","Male","Mice, Inbred C57BL","Mice","Imaging, Three-Dimensional","Atlases as Topic","Animals","Brain","Female","Magnetic Resonance Imaging","Article","Software"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T17:29:11.361570Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}