{"doi":"10.1101/2024.06.14.24308946","title":"Genome-wide association studies of lifetime and frequency cannabis use in 131,895 individuals","abstract":"Summary Cannabis is one of the most widely used drugs globally. Decriminalization of cannabis is further increasing cannabis consumption. We performed genome-wide association studies ( GWASs ) of lifetime ( N= 131,895) and frequency ( N= 73,374) of cannabis use. Lifetime cannabis use GWAS identified two loci, one near CADM2 (rs11922956, p =2.40E-11) and another near GRM3 (rs12673181, p =6.90E-09). Frequency of use GWAS identified one locus near CADM2 (rs4856591, p =8.10E-09; r 2 =0.76 with rs11922956). Both traits were heritable and genetically correlated with previous GWASs of lifetime use and cannabis use disorder ( CUD ), as well as other substance use and cognitive traits. Polygenic scores ( PGSs ) for lifetime and frequency of cannabis use associated cannabis use phenotypes in AllofUs participants. Phenome-wide association study of lifetime cannabis use PGS in a hospital cohort replicated associations with substance use and mood disorders, and uncovered associations with celiac and infectious diseases. This work demonstrates the value of GWASs of CUD transition risk factors.","journal":"medRxiv","year":2024,"id":487118,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9246,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":189,"name":"Pierre Fontanillas","orcid":"0000-0002-8944-4454","position":1,"is_corresponding":false},{"id":1119104,"name":"John J. Meredith","orcid":"0000-0001-6622-6414","position":2,"is_corresponding":false},{"id":565619,"name":"Mariela Jennings","orcid":null,"position":3,"is_corresponding":false},{"id":237635,"name":"Renata B. Cupertino","orcid":"0000-0002-3452-0632","position":4,"is_corresponding":false},{"id":1331480,"name":"Shreya Pakala","orcid":null,"position":5,"is_corresponding":false},{"id":188,"name":"Sarah L. Elson","orcid":"0000-0002-3211-3750","position":6,"is_corresponding":false},{"id":910445,"name":"Jibran Y. Khokhar","orcid":"0000-0002-2169-2275","position":7,"is_corresponding":false},{"id":11243,"name":"Lea K. Davis","orcid":"0000-0001-5143-2282","position":8,"is_corresponding":false},{"id":230001,"name":"Emma C. Johnson","orcid":"0000-0003-0394-777X","position":9,"is_corresponding":false},{"id":230002,"name":"Abraham A. Palmer","orcid":"0000-0003-3634-0747","position":10,"is_corresponding":false},{"id":85959,"name":"Sandra Sanchez-Roige","orcid":"0000-0001-6137-5699","position":11,"is_corresponding":false},{"id":1242535,"name":"Hayley H. A. Thorpe","orcid":"0000-0002-7263-637X","position":0,"is_corresponding":true}],"reference_count":145,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:06.013846Z","pmid":"38947071","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}