{"doi":"10.1101/2024.05.22.595232","title":"Rationally Minimizing Natural Product Libraries Using Mass Spectrometry","abstract":"Natural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":497923,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":746881,"name":"Thilini Peramuna","orcid":"0000-0002-9372-1370","position":1,"is_corresponding":false},{"id":431631,"name":"Karen Wendt","orcid":"0000-0002-3532-043X","position":2,"is_corresponding":false},{"id":752647,"name":"Jennifer E. Collins","orcid":"0000-0002-1195-4630","position":3,"is_corresponding":false},{"id":432939,"name":"Jarrod B. King","orcid":null,"position":4,"is_corresponding":false},{"id":1091411,"name":"Raphaella Paes","orcid":"0000-0002-6146-5309","position":5,"is_corresponding":false},{"id":1091410,"name":"Natalia Mojica Santos","orcid":"0000-0003-1892-1628","position":6,"is_corresponding":false},{"id":1344871,"name":"Crystal Okeke","orcid":null,"position":7,"is_corresponding":false},{"id":1344872,"name":"Cameron R. Miller","orcid":null,"position":8,"is_corresponding":false},{"id":497864,"name":"Debopam Chakrabarti","orcid":"0000-0002-4554-3119","position":9,"is_corresponding":false},{"id":422475,"name":"Robert H. Cichewicz","orcid":"0000-0003-0744-4117","position":10,"is_corresponding":false},{"id":105872,"name":"Laura‐Isobel McCall","orcid":"0000-0002-1243-8953","position":11,"is_corresponding":false},{"id":1124705,"name":"Monica Ness","orcid":null,"position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:09:38.543544Z","pmid":"38826280","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}