{"doi":"10.1101/2024.05.02.24305807","title":"An Accelerated PETALUTE MRI Sequence for <i>In Vivo</i> Quantification of Sodium Content in Human Articular Cartilage at 3T","abstract":"In this work, we demonstrate the sodium magnetic resonance imaging (MRI) capabilities of a three-dimensional (3D) dual-echo ultrashort echo time (UTE) sequence with a novel rosette petal trajectory (PETALUTE), in comparison to the 3D density-adapted (DA) radial spokes UTE sequence. We scanned five healthy subjects using a 3D dual-echo PETALUTE acquisition and two comparable implementations of 3D DA-radial spokes acquisitions, one matching the number of k-space projections (Radial-Matched Trajectories) and the other matching the total number of samples (Radial-Matched Samples) acquired in k-space. The PETALUTE acquisition enabled equivalent sodium quantification in articular cartilage volumes of interest (168.8 ± 29.9 mM) to those derived from the 3D radial acquisitions (171.62 ± 28.7 mM and 149.8 ± 22.2 mM, respectively). We achieved a shorter scan time of 2:06 for 3D PETALUTE, compared to 3:36 for 3D radial acquisitions. We also evaluated the feasibility of further acceleration of the PETALUTE sequence through retrospective compressed sensing with 2× and 4× acceleration of the first echo and showed structural similarity of 0.89 ± 0.03 and 0.87 ± 0.03 when compared to non-retrospectively accelerated reconstruction. Together, these results demonstrate improved scan time with equivalent performance of the PETALUTE sequence compared to the 3D DA-radial sequence for sodium MRI of articular cartilage.","journal":"medRxiv","year":2024,"id":490860,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9666,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":407452,"name":"Xin Shen","orcid":"0000-0003-0184-8751","position":1,"is_corresponding":false},{"id":407451,"name":"Ahmad A. Alhulail","orcid":"0000-0002-6393-5415","position":2,"is_corresponding":false},{"id":1313665,"name":"Nicholas M. Buffo","orcid":null,"position":3,"is_corresponding":false},{"id":453344,"name":"Xiaopeng Zhou","orcid":"0000-0002-0650-183X","position":4,"is_corresponding":false},{"id":1313666,"name":"Evan Pogue","orcid":null,"position":5,"is_corresponding":false},{"id":817951,"name":"Ali Çağlar Özen","orcid":"0000-0003-3536-0826","position":6,"is_corresponding":false},{"id":817953,"name":"Mark Chiew","orcid":"0000-0001-6272-8783","position":7,"is_corresponding":false},{"id":268807,"name":"Stephen J. Sawiak","orcid":"0000-0003-4210-9816","position":8,"is_corresponding":false},{"id":407457,"name":"Uzay E. Emir","orcid":"0000-0001-5376-0431","position":9,"is_corresponding":false},{"id":947257,"name":"Deva D. Chan","orcid":"0000-0003-1508-1045","position":10,"is_corresponding":false},{"id":1313278,"name":"Cameron Villarreal","orcid":"0000-0002-1779-1203","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:08:37.162700Z","pmid":"38746343","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}