{"doi":"10.1101/2024.04.28.591561","title":"Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine","abstract":"Ferroptosis is a cell death mechanism that has attracted significant attention as a potential basis for the development of new cancer therapies. Validation of ferroptosis biology in species commonly used in translation and pre-clinical development is a necessary foundation for enabling the advancement of such ferroptosis modulating drugs. Here, we demonstrate that canine cancer cells exhibit sensitivity to a wide range of ferroptosis-inducing perturbations in a manner indistinguishable from human cancer cells, and recapitulate characteristic patterns of ferroptotic response across tumor types seen in the human setting. The foundation provided herein establishes the dog as a relevant efficacy and toxicology model for ferroptosis and creates new opportunities to leverage the canine comparative oncology paradigm to accelerate the development of ferroptosis-inducing drugs for human cancer patients.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":490841,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":250855,"name":"Gang Xing","orcid":"0000-0001-8857-9421","position":1,"is_corresponding":false},{"id":229705,"name":"Laura Furst","orcid":null,"position":2,"is_corresponding":false},{"id":1336336,"name":"Krishna Dave","orcid":null,"position":3,"is_corresponding":false},{"id":1114301,"name":"Qiong Zhou","orcid":"0009-0005-9161-3009","position":4,"is_corresponding":false},{"id":469872,"name":"Daniel V. LaBarbera","orcid":"0000-0001-9460-3862","position":5,"is_corresponding":false},{"id":643024,"name":"Douglas H. Thamm","orcid":"0000-0002-8914-7767","position":6,"is_corresponding":false},{"id":227619,"name":"John K. Eaton","orcid":"0000-0003-4633-5546","position":7,"is_corresponding":false},{"id":678158,"name":"Mathias J. Wawer","orcid":"0000-0001-6664-0930","position":9,"is_corresponding":false},{"id":227628,"name":"Vasanthi S. Viswanathan","orcid":"0000-0001-9878-3629","position":11,"is_corresponding":false},{"id":366507,"name":"Priya Chatterji","orcid":"0000-0001-7792-9078","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:08:37.162700Z","pmid":"38746359","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}