{"doi":"10.1101/2024.04.05.588359","title":"Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera","abstract":"Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vaccinations. Here, we show that neutralization titers and breadth of matched human and hamster pre-Omicron variant primary infection sera correlate well and generate similar antigenic maps. The hamster antigenic map shows modest antigenic drift among XBB sub-lineage variants, with JN.1 and BA.4/BA.5 variants within the XBB cluster, but with five to six-fold antigenic differences between these variants and XBB.1.5. Compared to sera following only ancestral or bivalent COVID-19 vaccinations, or with post-vaccination infections, XBB.1.5 booster sera had the broadest neutralization against XBB sub-lineage variants, although a five-fold titer difference was still observed between JN.1 and XBB.1.5 variants. These findings suggest that antibody coverage of antigenically divergent JN.1 could be improved with a matched vaccine antigen.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":485116,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323542,"name":"Gitanjali Bhushan","orcid":"0000-0002-6463-9394","position":1,"is_corresponding":false},{"id":1246769,"name":"Stephanie Paz","orcid":null,"position":2,"is_corresponding":false},{"id":320714,"name":"Charles B. Stauft","orcid":"0000-0001-5633-2950","position":3,"is_corresponding":false},{"id":1328155,"name":"Prabhu Selvaraj","orcid":null,"position":4,"is_corresponding":false},{"id":650256,"name":"Emilie Goguet","orcid":"0000-0001-6284-4346","position":5,"is_corresponding":false},{"id":802761,"name":"Kimberly A. Bishop‐Lilly","orcid":"0000-0002-5744-8493","position":6,"is_corresponding":false},{"id":581015,"name":"Rahul Subramanian","orcid":"0000-0002-1131-9952","position":7,"is_corresponding":false},{"id":804246,"name":"Russell Vassell","orcid":"0000-0002-2295-5890","position":8,"is_corresponding":false},{"id":334607,"name":"Sabrina Lusvarghi","orcid":"0000-0003-1793-0450","position":9,"is_corresponding":false},{"id":629978,"name":"Yu Cong","orcid":"0000-0001-5037-0729","position":10,"is_corresponding":false},{"id":404703,"name":"Brian K. Agan","orcid":"0000-0002-5114-1669","position":11,"is_corresponding":false},{"id":536243,"name":"Stephanie A Richard","orcid":"0000-0002-0530-384X","position":12,"is_corresponding":false},{"id":557984,"name":"Nusrat J Epsi","orcid":"0000-0001-5363-075X","position":13,"is_corresponding":false},{"id":696869,"name":"Anthony C Fries","orcid":"0000-0001-7556-1353","position":14,"is_corresponding":false},{"id":497141,"name":"Christian Fung","orcid":"0000-0002-8709-5932","position":15,"is_corresponding":false},{"id":393186,"name":"Matthew A. Conte","orcid":"0000-0003-2712-7960","position":16,"is_corresponding":false},{"id":294669,"name":"Michael R. Holbrook","orcid":"0000-0002-0824-2667","position":17,"is_corresponding":false},{"id":313412,"name":"Tony T. Wang","orcid":"0000-0001-8983-1721","position":18,"is_corresponding":false},{"id":103453,"name":"Timothy Burgess","orcid":"0000-0003-1247-8370","position":19,"is_corresponding":false},{"id":516466,"name":"Edward Mitre","orcid":"0000-0001-7506-3266","position":20,"is_corresponding":false},{"id":650258,"name":"Simon Pollett","orcid":"0000-0003-2643-4213","position":21,"is_corresponding":false},{"id":107129,"name":"Leah C. Katzelnick","orcid":"0000-0003-1033-6758","position":22,"is_corresponding":false},{"id":804247,"name":"Carol D. Weiss","orcid":"0000-0002-9965-1289","position":23,"is_corresponding":false},{"id":882454,"name":"Wei Wang","orcid":"0000-0001-7788-1895","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:07:47.633574Z","pmid":"38712124","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}