{"doi":"10.1101/2024.04.05.24305377","title":"Personalized prediction of UTI risk and antibiotic susceptibility based on gut <i>E. coli</i>","abstract":"Abstract Community-acquired UTI is the most common bacterial infection. We assessed whether gut Escherichia coli profiles are associated with UTI risk and pathogen antibiotic susceptibility in women aged ≥50, antibiotics-free for ≥1 year. In an 18-month prospective observational study, 1,804 participants provided a baseline fecal sample screened for E. coli abundance, resistance to trimethoprim/sulfamethoxazole, ciprofloxacin, and third-generation cephalosporins, and association with pandemic multidrug-resistant (MDR) clonal groups ST131- H30 and ST1193. E. coli was present in 90.8% of samples; 37.5% showed resistance to one or more antibiotics. MDR strains were highly abundant in the gut, with ST131- H30 carriage increasing and ST1193 declining with age. During the 18-months follow-up, UTIs occurred in 10.9% of E. coli carriers versus 3.3% of non-carriers (P=.003), with the highest risk of 37.8% observed among women ≥70 yo colonized with ST131- H30 . Increased fecal abundance of strains resistant to the antibiotics strongly associated with the UTI risk. The original fecal E. coli resistance profiles were concordant with UTI antibiotic susceptibility with 95–100% accuracy in 95% of patients.","journal":"Journal of Business Administration (JBA)","year":2024,"id":490600,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":624929,"name":"Debarati Choudhury","orcid":null,"position":1,"is_corresponding":false},{"id":624019,"name":"Lydia Larson","orcid":"0000-0001-6944-3940","position":2,"is_corresponding":false},{"id":1047033,"name":"Irina Basova","orcid":null,"position":3,"is_corresponding":false},{"id":624928,"name":"Yulia Sledneva","orcid":null,"position":4,"is_corresponding":false},{"id":1336182,"name":"Teresa Cristina Bonilla","orcid":null,"position":5,"is_corresponding":false},{"id":1046609,"name":"Thalia Solyanik","orcid":"0009-0004-8731-2177","position":6,"is_corresponding":false},{"id":1046610,"name":"Jennifer Heng","orcid":"0009-0001-2067-557X","position":7,"is_corresponding":false},{"id":1336183,"name":"Isaac Pasumansky","orcid":null,"position":8,"is_corresponding":false},{"id":624925,"name":"Victoria Bowers","orcid":null,"position":9,"is_corresponding":false},{"id":1047035,"name":"Sophia Pham","orcid":null,"position":10,"is_corresponding":false},{"id":1047037,"name":"Lawrence Madziwa","orcid":null,"position":11,"is_corresponding":false},{"id":948856,"name":"Erika Holden","orcid":null,"position":12,"is_corresponding":false},{"id":660407,"name":"Sara Y. Tartof","orcid":"0000-0003-2336-8476","position":15,"is_corresponding":false},{"id":678774,"name":"James D. Ralston","orcid":"0000-0003-0014-2212","position":16,"is_corresponding":false},{"id":624024,"name":"Evgeni V. Sokurenko","orcid":"0000-0003-2806-4121","position":17,"is_corresponding":false},{"id":624018,"name":"Veronika Tchesnokova","orcid":"0000-0002-4235-5796","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T02:08:37.162700Z","pmid":"38645148","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}