{"doi":"10.1101/2024.03.28.587148","title":"Transcriptomic Changes in Oligodendrocyte Lineage Cells During the Juvenile to Adult Transition in the Mouse Corpus Callosum","abstract":"Abstract The corpus callosum, a major white matter tract in the brain, undergoes age-related functional changes. To extend our investigation of age-related gene expression dynamics in the mouse corpus callosum, we compared RNA-seq data from 2-week-old and 12-week-old wild-type C57BL/6J mice and identified the differentially expressed genes (e.g., Serpinb1a, Ndrg1, Dnmt3a , etc.) between these ages. Interestingly, we found that genes highly expressed in myelinating oligodendrocytes were upregulated in 12-week-old mice compared to 2-week-old mice, while genes highly expressed in oligodendrocyte precursor cells (OPCs) and newly formed oligodendrocytes were downregulated. Furthermore, by comparing these genes with the datasets from 20-week-old and 96-week-old mice, we identified novel sets of genes with age-dependent variations in the corpus callosum. These gene expression changes potentially affect key biological pathways and may be closely linked to age-related neurological disorders, including dementia and stroke. Therefore, our results provide an additional dataset to explore age-dependent gene expression dynamics of oligodendrocyte lineage cells in the corpus callosum.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":496103,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9425,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":383537,"name":"Hajime Takase","orcid":"0000-0001-5813-1386","position":1,"is_corresponding":false},{"id":383535,"name":"Gen Hamanaka","orcid":"0000-0003-0957-2817","position":2,"is_corresponding":false},{"id":1073922,"name":"Shintaro Kimura","orcid":"0000-0002-1122-3395","position":3,"is_corresponding":false},{"id":1084625,"name":"Norito Fukuda","orcid":"0000-0002-1548-0516","position":4,"is_corresponding":false},{"id":418234,"name":"Emiri T. Mandeville","orcid":"0000-0002-7680-0923","position":5,"is_corresponding":false},{"id":383539,"name":"Josephine Lok","orcid":"0000-0001-8320-0961","position":6,"is_corresponding":false},{"id":279631,"name":"Eng H. Lo","orcid":"0000-0002-9327-2915","position":7,"is_corresponding":false},{"id":383540,"name":"Ken Arai","orcid":"0000-0003-1615-3258","position":8,"is_corresponding":false},{"id":1257500,"name":"Tomonori Hoshino","orcid":"0000-0002-2737-5326","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T02:09:23.333150Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}