{"doi":"10.1101/2024.03.27.587112","title":"Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships","abstract":"As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment profoundly shapes transcription in the NAc. This provides a potential biological mechanism by which shared social experience reinforces and strengthens relationships.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":485102,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9344,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1057036,"name":"Julie M. Sadino","orcid":"0000-0002-2330-6198","position":1,"is_corresponding":false},{"id":813755,"name":"Allison C. Fultz","orcid":null,"position":2,"is_corresponding":false},{"id":832150,"name":"Michael A. Kelberman","orcid":"0000-0001-8158-8624","position":3,"is_corresponding":false},{"id":28295,"name":"Robin D. Dowell","orcid":"0000-0001-7665-9985","position":4,"is_corresponding":false},{"id":355216,"name":"Mary Allen","orcid":"0000-0001-8163-0714","position":5,"is_corresponding":false},{"id":300989,"name":"Zoe R. Donaldson","orcid":"0000-0001-6699-7905","position":6,"is_corresponding":false},{"id":813118,"name":"Liza E. Brusman","orcid":"0000-0002-1833-5939","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:07:47.633574Z","pmid":"39605537","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}