{"doi":"10.1101/2024.03.19.24304407","title":"Language Abnormalities in Alzheimer’s Disease Arise from Reduced Informativeness: A Cross-Linguistic Study in English and Persian","abstract":"INTRODUCTION: This research investigates the psycholinguistic origins of language impairments in Alzheimer's Disease (AD), questioning if these impairments result from language-specific structural disruptions or from a universal deficit in generating meaningful content. METHODS: Cross-linguistic analysis was conducted on language samples from 184 English and 52 Persian speakers, comprising both AD patients and healthy controls, to extract various language features. Furthermore, we introduced a machine learning-based metric, Language Informativeness Index (LII), to quantify informativeness. RESULTS: Indicators of AD in English were found to be highly predictive of AD in Persian, with a 92.3% classification accuracy. Additionally, we found robust correlations between the typical linguistic abnormalities of AD and language emptiness (low LII) across both languages. DISCUSSION: Findings suggest AD linguistics impairments are attributed to a core universal difficulty in generating informative messages. Our approach underscores the importance of incorporating biocultural diversity into research, fostering the development of inclusive diagnostic tools.","journal":"medRxiv","year":2024,"id":495574,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1342357,"name":"Mahya Santai","orcid":null,"position":1,"is_corresponding":false},{"id":1331350,"name":"Mehrdad Mohammad Panahi","orcid":null,"position":2,"is_corresponding":false},{"id":1257388,"name":"Amirhossein Khodadadi","orcid":"0009-0005-4413-5614","position":3,"is_corresponding":false},{"id":1342358,"name":"Mahdieh Ghassimi","orcid":null,"position":4,"is_corresponding":false},{"id":1099076,"name":"Sahar Rezaei","orcid":null,"position":5,"is_corresponding":false},{"id":1257389,"name":"Sara Besharat","orcid":"0000-0003-2199-3956","position":6,"is_corresponding":false},{"id":1342359,"name":"Zahra Mahboubi","orcid":null,"position":7,"is_corresponding":false},{"id":1022612,"name":"Mostafa Almasi‐Dooghaee","orcid":"0000-0002-3244-1615","position":8,"is_corresponding":false},{"id":1331005,"name":"Morteza Sanei Taheri","orcid":"0000-0002-8881-9058","position":9,"is_corresponding":false},{"id":19606,"name":"Bradford C. Dickerson","orcid":"0000-0002-5958-3445","position":10,"is_corresponding":false},{"id":987260,"name":"Neguine Rezaii","orcid":"0000-0002-8967-9237","position":11,"is_corresponding":false},{"id":1257868,"name":"Sabereh Bayat","orcid":null,"position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:09:19.627139Z","pmid":"38562858","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}