{"doi":"10.1101/2024.03.06.24303876","title":"Neuroanatomical variability associated with early substance use initiation: Results from the ABCD Study","abstract":"Abstract The extent to which neuroanatomical variability associated with substance involvement reflects pre-existing risk and/or consequences of substance exposure remains poorly understood. In the Adolescent Brain Cognitive Development SM (ABCD®) Study, we identify associations between global and regional differences in brain structure and early substance use initiation (i.e., occurring <15 years of age; ns analytic =6,556-9,804), with evidence that associations precede initiation. Neurodevelopmental variability in brain structure may confer risk for substance involvement.","journal":"medRxiv","year":2024,"id":485071,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9414,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230695,"name":"David A. A. Baranger","orcid":"0000-0002-6659-357X","position":1,"is_corresponding":false},{"id":230693,"name":"Sarah E. Paul","orcid":"0000-0003-0320-7907","position":2,"is_corresponding":false},{"id":285456,"name":"Hugh Garavan","orcid":"0000-0002-8939-1014","position":3,"is_corresponding":false},{"id":350391,"name":"Scott Mackey","orcid":"0000-0001-7817-7437","position":4,"is_corresponding":false},{"id":341671,"name":"Susan F. Tapert","orcid":"0000-0001-7259-6112","position":5,"is_corresponding":false},{"id":630288,"name":"Kimberly H. LeBlanc","orcid":"0000-0002-9333-5963","position":6,"is_corresponding":false},{"id":230004,"name":"Arpana Agrawal","orcid":"0000-0002-0313-793X","position":7,"is_corresponding":false},{"id":232788,"name":"Ryan Bogdan","orcid":"0000-0002-1430-1045","position":8,"is_corresponding":false},{"id":1013136,"name":"Alex P. Miller","orcid":"0000-0001-9163-8947","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:07:47.633574Z","pmid":"38496425","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}