{"doi":"10.1101/2024.02.23.24303277","title":"Polygenic Prediction of Cellular Immune Responses to Mumps Vaccine","abstract":"In this report, we provide a follow-up analysis of a previously published genome-wide association study of host genetic variants associated with inter-individual variations in cellular immune responses to mumps vaccine. Here we report the results of a polygenic score (PGS) analysis showing how common variants can predict mumps vaccine response. We found higher PGS for IFNγ, IL-2, and TNFα were predictive of higher post-vaccine IFNγ (p-value = 2e-6), IL-2 (p = 2e-7), and TNFα (p = 0.004) levels, respectively. Control of immune responses after vaccination is complex and polygenic in nature. Our results suggest that the PGS-based approach enables better capture of the combined genetic effects that contribute to mumps vaccine-induced immunity, potentially offering a more comprehensive understanding than traditional single-variant GWAS. This approach will likely have broad utility in studying genetic control of immune responses to other vaccines and to infectious diseases.","journal":"medRxiv","year":2024,"id":494646,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9385,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275824,"name":"Inna G. Ovsyannikova","orcid":"0000-0003-1506-9214","position":1,"is_corresponding":false},{"id":72550,"name":"Daniel J. Schaid","orcid":"0000-0003-1457-6433","position":2,"is_corresponding":false},{"id":374144,"name":"Nathaniel D. Warner","orcid":"0000-0001-9584-5257","position":3,"is_corresponding":false},{"id":275825,"name":"Gregory A. Poland","orcid":"0000-0001-5057-4457","position":4,"is_corresponding":false},{"id":275823,"name":"Richard B. Kennedy","orcid":"0000-0001-6164-4967","position":5,"is_corresponding":false},{"id":471881,"name":"Brandon J. Coombes","orcid":"0000-0003-4322-5923","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:09:11.736910Z","pmid":"38464113","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}