{"doi":"10.1101/2024.02.16.580701","title":"Intrinsic structural covariation links cerebellum subregions to the cerebral cortex","abstract":"Abstract The human cerebellum is increasingly recognized to be involved in non-motor and higher-order cognitive functions. Yet, its ties with the entire cerebral cortex have not been holistically studied in a whole-brain exploration with a unified analytical framework. Here, we characterized disso-ciable cortical-cerebellar structural covariation patterns across the brain in n=38,527 UK Bio-bank participants. Our results invigorate previous observations in that important shares of corti-cal-cerebellar structural covariation are described as i) a dissociation between the higher-level cognitive system and lower-level sensorimotor system, as well as ii) an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel pattern of ipsilateral, rather than contralateral, cerebral-cerebellar associations. Furthermore, phenome-wide association assays revealed key phenotypes, including cognitive phenotypes, lifestyle, physical properties, and blood assays, associated with each decomposed covariation pattern, helping to understand their real-world implications. This systems neurosci-ence view paves the way for future studies to explore the implications of these structural covaria-tions, potentially illuminating new pathways in our understanding of neurological and cognitive disorders.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":486727,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9068,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244635,"name":"Jörn Diedrichsen","orcid":"0000-0003-0264-8532","position":1,"is_corresponding":false},{"id":961656,"name":"Karin Saltoun","orcid":"0000-0003-0971-1266","position":2,"is_corresponding":false},{"id":564696,"name":"Christopher J. Steele","orcid":"0000-0003-1656-7928","position":3,"is_corresponding":false},{"id":1281143,"name":"Sheeba Rani Arnold-Anteraper","orcid":null,"position":4,"is_corresponding":false},{"id":30836,"name":"B.T. Thomas Yeo","orcid":"0000-0002-0119-3276","position":5,"is_corresponding":false},{"id":228120,"name":"Jeremy D. Schmahmann","orcid":"0000-0003-0706-5125","position":6,"is_corresponding":false},{"id":18614,"name":"Danilo Bzdok","orcid":"0000-0003-3466-6620","position":7,"is_corresponding":false},{"id":1280670,"name":"Zilong Wang","orcid":"0009-0000-5600-7437","position":0,"is_corresponding":true}],"reference_count":182,"raw_metadata":null,"created_at":"2026-07-19T02:08:01.404471Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}