{"doi":"10.1101/2024.02.12.579969","title":"Evaluation of a novel Tc-24 recombinant antigen ELISA for serologic testing for <i>Trypanosoma cruzi</i> in dogs","abstract":"Abstract Chagas disease is a parasitic infection caused by Trypanosoma cruzi . Diagnosis of chroni Chagas disease in dogs relies on limited serological test options. This study used a new Tc-24 recombinant antigen ELISA on an archival set of 70 dog serum samples from multi-dog kennel environments in Texas subjected to three existing Chagas serological tests. Tc-24 ELISA produced a quantitative result and could detect anti- T. cruzi antibodies in dogs with high sensitivity and specificity. Comparing individual tests to Tc-24 ELISA resulted in strong associations and correlations, which suggest that Tc-24 ELISA is a reliable and accurate diagnostic tool for dogs with a single test.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":494442,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":773640,"name":"Guilherme G. Verocai","orcid":"0000-0002-4543-7105","position":1,"is_corresponding":false},{"id":1142984,"name":"Ilana A. Mosley","orcid":"0000-0002-1863-4824","position":2,"is_corresponding":false},{"id":342530,"name":"Bin Zhan","orcid":"0000-0002-6884-9452","position":3,"is_corresponding":false},{"id":1341225,"name":"Lindsey Vongthavaravat","orcid":null,"position":4,"is_corresponding":false},{"id":680172,"name":"Rachel E. Busselman","orcid":"0000-0001-6315-5040","position":5,"is_corresponding":false},{"id":366044,"name":"Sarah A. Hamer","orcid":"0000-0002-4955-048X","position":6,"is_corresponding":false},{"id":361222,"name":"Rojelio Mejía","orcid":"0000-0003-4134-4558","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:09:11.736910Z","pmid":"38405948","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}