{"doi":"10.1101/2024.02.03.578750","title":"Inferring the Joint Distribution of Structural and Functional Connectivity in the Human Brain using UNIT-DDPM","abstract":"A bstract The structural wiring of the brain is expected to produce a repertoire of functional networks, across time, context, individuals and vice versa. Therefore, a method to infer the joint distribution of structural and functional connectomes would be of immense value. However, existing approaches only provide deterministic snapshots of the structure-function relationship. Here we use an unpaired image translation method, UNIT-DDPM, that infers a joint distribution of structural and functional connectomes. Our approach allows estimates of variability of function for a given structure and vice versa. Furthermore, we found a significant improvement in prediction accuracy among individual brain networks, implicating a tighter coupling of structure and function than previously understood. Also, our approach has the ad-vantage of not relying on paired samples for training. This novel approach provides a means for identifying regions of consistent structure-function coupling.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":494204,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9331,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1340876,"name":"Varun Canamedi","orcid":null,"position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T02:09:07.920649Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}