{"doi":"10.1101/2024.01.22.575730","title":"TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes","abstract":"Abstract In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternative polyadenylation, impacting expression of disease-relevant genes (e.g., ELP1, NEFL, and TMEM106B ) and providing evidence that alternative polyadenylation is a new facet of TDP-43 pathology.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":483972,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1325456,"name":"Anastasiia Lovchykova","orcid":"0009-0008-5895-0259","position":1,"is_corresponding":false},{"id":822849,"name":"Tetsuya Akiyama","orcid":"0000-0002-8076-1242","position":2,"is_corresponding":false},{"id":109073,"name":"Chang Liu","orcid":"0000-0001-5219-1089","position":3,"is_corresponding":false},{"id":288607,"name":"Caiwei Guo","orcid":"0000-0002-9975-9732","position":4,"is_corresponding":false},{"id":1206722,"name":"Vidhya Maheswari Jawahar","orcid":null,"position":5,"is_corresponding":false},{"id":1326121,"name":"Odilia Sianto","orcid":null,"position":6,"is_corresponding":false},{"id":1205891,"name":"Anna Calliari","orcid":"0009-0006-6834-0425","position":7,"is_corresponding":false},{"id":238155,"name":"Mercedes Prudencio","orcid":"0000-0002-4894-4858","position":8,"is_corresponding":false},{"id":54753,"name":"Dennis W. Dickson","orcid":"0000-0001-7189-7917","position":9,"is_corresponding":false},{"id":228616,"name":"Leonard Petrucelli","orcid":"0000-0003-2959-129X","position":10,"is_corresponding":false},{"id":230690,"name":"Aaron D. Gitler","orcid":"0000-0001-8603-1526","position":11,"is_corresponding":false},{"id":238000,"name":"Yi Zeng","orcid":"0000-0002-5477-6686","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T02:07:38.055693Z","pmid":"38328059","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}