{"doi":"10.1101/2024.01.20.576455","title":"Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development","abstract":"Within the adult rodent hippocampus, opioids suppress inhibitory parvalbumin-expressing interneurons (PV-INs), thus disinhibiting local micro-circuits. However, it is unknown if this disinhibitory motif is conserved in other cortical regions, species, or across development. We observed that PV-IN mediated inhibition is robustly suppressed by opioids in hippocampus proper but not primary neocortex in mice and nonhuman primates, with spontaneous inhibitory tone in resected human tissue also following a consistent dichotomy. This hippocampal disinhibitory motif was established in early development when PV-INs and opioids were found to regulate early population activity. Acute opioid-mediated modulation was partially occluded with morphine pretreatment, with implications for the effects of opioids on hippocampal network activity important for learning and memory. Together, these findings demonstrate that PV-INs exhibit a divergence in opioid sensitivity across brain regions that is remarkably conserved across evolution and highlights the underappreciated role of opioids acting through immature PV-INs in shaping hippocampal development.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":486594,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9439,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":773918,"name":"Anna Vlachos","orcid":"0000-0002-4411-9447","position":1,"is_corresponding":false},{"id":1330810,"name":"Nadiya McLean","orcid":null,"position":2,"is_corresponding":false},{"id":815929,"name":"Sarah Kimmel","orcid":null,"position":3,"is_corresponding":false},{"id":1330407,"name":"June Hoan Kim","orcid":"0000-0001-9078-6892","position":4,"is_corresponding":false},{"id":355199,"name":"Geoffrey Vargish","orcid":"0000-0002-2873-6517","position":5,"is_corresponding":false},{"id":325345,"name":"Vivek Mahadevan","orcid":"0000-0002-0805-827X","position":6,"is_corresponding":false},{"id":395691,"name":"Lauren T. 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