{"doi":"10.1101/2024.01.14.575588","title":"Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2","abstract":"SUMMARY Although vaccines have reduced COVID-19 disease burden, their efficacy in helminth infection endemic areas is not well characterized. We evaluated the impact of infection by Heligmosomoides polygyrus bakeri (Hpb), a murine intestinal hookworm, on the efficacy of an mRNA vaccine targeting the Wuhan-1 spike protein of SARS-CoV-2. Although immunization generated similar B cell responses in Hpb-infected and uninfected mice, polyfunctional CD4 + and CD8 + T cell responses were markedly reduced in Hpb-infected mice. Hpb-infected and mRNA vaccinated mice were protected against the ancestral SARS-CoV-2 strain WA1/2020, but control of lung infection was diminished against an Omicron variant compared to animals immunized without Hpb infection. Helminth mediated suppression of spike-specific CD8 + T cell responses occurred independently of STAT6 signaling, whereas blockade of IL-10 rescued vaccine-induced CD8 + T cell responses. In mice, intestinal helminth infection impairs vaccine induced T cell responses via an IL-10 pathway and compromises protection against antigenically shifted SARS-CoV-2 variants.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":489665,"datarank":0.15169970964086352,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.04772763255687171,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.04772763255687171,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":804573,"name":"Courtney E. Karl","orcid":"0000-0001-9950-2155","position":1,"is_corresponding":false},{"id":408059,"name":"Baoling Ying","orcid":null,"position":2,"is_corresponding":false},{"id":464971,"name":"Chieh-Yu Liang","orcid":"0000-0003-4624-7212","position":3,"is_corresponding":false},{"id":480719,"name":"Tamara García‐Salum","orcid":"0000-0002-0170-9965","position":4,"is_corresponding":false},{"id":372781,"name":"Ana Carolina Santana","orcid":null,"position":5,"is_corresponding":false},{"id":1049860,"name":"Felipe ten-Caten","orcid":"0000-0001-7771-1490","position":6,"is_corresponding":false},{"id":258973,"name":"Joseph F. Urban","orcid":"0000-0002-1590-8869","position":7,"is_corresponding":false},{"id":75378,"name":"Sayda M. Elbashir","orcid":"0000-0001-6250-9679","position":8,"is_corresponding":false},{"id":105569,"name":"Darin K. Edwards","orcid":"0000-0002-2065-2941","position":9,"is_corresponding":false},{"id":244982,"name":"Susan Pereira Ribeiro","orcid":"0000-0002-3127-3138","position":10,"is_corresponding":false},{"id":106528,"name":"Larissa B. Thackray","orcid":"0000-0002-9380-6569","position":11,"is_corresponding":false},{"id":244983,"name":"Rafick‐Pierre Sékaly","orcid":"0000-0002-7816-4828","position":12,"is_corresponding":false},{"id":106529,"name":"Michael Diamond","orcid":"0000-0002-8791-3165","position":13,"is_corresponding":false},{"id":652105,"name":"Pritesh Desai","orcid":"0000-0002-4697-9475","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:28.548530Z","pmid":"38293221","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}