{"doi":"10.1101/2024.01.11.575258","title":"Defining the contribution of\n                  <i>Troy</i>\n                  -positive progenitor cells to the mouse esophageal epithelium","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Progenitor cells adapt their behavior in response to tissue demands. However, the molecular mechanisms controlling esophageal progenitor decisions remain largely unknown. Here we demonstrate the presence of a\n                  <jats:italic>Troy</jats:italic>\n                  (\n                  <jats:italic>Tnfrsf19</jats:italic>\n                  )-expressing progenitor subpopulation localized to defined regions along the mouse esophageal axis. Lineage tracing and mathematical modelling demonstrate that\n                  <jats:italic>Troy-</jats:italic>\n                  positive progenitor cells are prone to undergoing symmetrical fate choices and contribute to esophageal tissue homeostasis long-term. Functionally, TROY inhibits progenitor proliferation and enables commitment to differentiation without affecting fate symmetry. Whereas\n                  <jats:italic>Troy</jats:italic>\n                  expression is stable during esophageal homeostasis, progenitor cells downregulate\n                  <jats:italic>Troy</jats:italic>\n                  in response to tissue stress, enabling proliferative expansion of basal cells refractory to differentiation and reestablishment of tissue homeostasis. Our results demonstrate functional, spatially restricted, progenitor heterogeneity in the esophageal epithelium and identify how dynamic regulation of\n                  <jats:italic>Troy</jats:italic>\n                  coordinates tissue generation.\n                </jats:p>","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":null,"id":33864,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":120710,"name":"Menghan Wang","orcid":null,"position":1,"is_corresponding":false},{"id":176381,"name":"Evelien Eenjes","orcid":"0000-0001-7108-0659","position":2,"is_corresponding":false},{"id":176382,"name":"Maja Svetličič","orcid":null,"position":3,"is_corresponding":false},{"id":176383,"name":"Qiaolin Deng","orcid":null,"position":4,"is_corresponding":false},{"id":176384,"name":"Pontus Giselsson","orcid":null,"position":5,"is_corresponding":false},{"id":176385,"name":"Maria Genander","orcid":"0000-0002-2428-8040","position":6,"is_corresponding":false},{"id":176380,"name":"David Grommisch","orcid":"0000-0002-2666-1419","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38565145","pmcid":null,"openalex_id":"https://openalex.org/W4390824550","authors":[],"funders":[{"funder_name":"Swedish Cancer Society","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Commission","grant_id":"851241","title":"Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinoma"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2024,"count":1}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2024/03/21/2024.01.11.575258.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2024/03/21/2024.01.11.575258.full.pdf","host_type":"GREEN"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2024/03/21/2024.01.11.575258.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2024.01.11.575258","host_type":"publisher"},{"url":"https://doi.org/10.1101/2024.01.11.575258","host_type":"repository"},{"url":"https://doi.org/10.1016/j.devcel.2024.03.011","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/38565145","host_type":""},{"url":"https://publications.scilifelab.se/publication/9aa0722104fb4d088f7b2eed26775252","host_type":""}],"fields_of_study":["Cancer-related gene regulation","Wnt/β-catenin signaling in development and cancer","Kruppel-like factors research","Medicine","Biology"],"mesh_terms":[],"keywords":["Progenitor cell","Progenitor","Epithelium","Cell biology","Biology","Stem cell","Medicine","Pathology","Homeodomain Proteins","Mice","Esophageal Mucosa","Esophagus","Stem Cells","Animals","Homeostasis","Cell Differentiation","Cell Lineage","Receptors, Tumor Necrosis Factor","Cell Proliferation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T17:05:00.103528Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}