{"doi":"10.1101/2023.12.21.572595","title":"Western diet feeding since adolescence impairs functional hyperemia probed by functional ultrasound imaging at adulthood and middle age: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio in the diet","abstract":"Abstract Obesity is a devastating worldwide metabolic disease, with the highest prevalence in children and adolescence. Obesity impacts neuronal function but the fate of functional hyperemia, a vital mechanism making possible cerebral blood supply to active brain areas, is unknown in organisms fed a high caloric Western Diet (WD) since adolescence. We mapped changes in cerebral blood volume (CBV) in the somatosensory cortex in response to whiskers stimulation in adolescent, adult and middle-aged mice fed a WD since adolescence. To this aim, we used non-invasive and high-resolution functional ultrasound imaging (fUS). Functional hyperemia is compromised as early as 3 weeks of WD and remains impaired thereafter. Starting WD in adult mice does not trigger the profound impairment in sensory-evoked CBV observed in young mice, suggesting a cerebrovascular vulnerability to WD during adolescence. A balanced ω-6:ω-3 polyunsaturated fatty acids ratio in WD achieved by docosahexaenoic acid supplementation is efficient to restore glucose homeostasis and functional hyperemia in adults.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":415331,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1197615,"name":"Clémentine Morisset","orcid":null,"position":1,"is_corresponding":false},{"id":1197364,"name":"Mireia Montaner","orcid":"0009-0007-4232-482X","position":2,"is_corresponding":false},{"id":1197365,"name":"Frédéric Pain","orcid":"0000-0001-9854-6025","position":3,"is_corresponding":false},{"id":427730,"name":"Chr̀istophe Magnan","orcid":"0000-0002-7044-2571","position":4,"is_corresponding":false},{"id":457159,"name":"Mickaël Tanter","orcid":"0000-0001-7739-8051","position":5,"is_corresponding":false},{"id":1197366,"name":"Hirac Gurden","orcid":"0000-0003-0027-4717","position":6,"is_corresponding":false},{"id":1197614,"name":"Haleh Soleimanzad","orcid":null,"position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T01:22:12.933438Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}