{"doi":"10.1101/2023.12.19.572454","title":"A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients","abstract":"We developed a computational pipeline (now provided as a resource) for measuring morphological similarity between cortical surface sulci to construct a sulcal phenotype network (SPN) from each magnetic resonance imaging (MRI) scan in an adult cohort (N=34,725; 45-82 years). Networks estimated from pairwise similarities of 40 sulci on 5 morphological metrics comprised two clusters of sulci, represented also by the bipolar distribution of sulci on a linear-to-complex dimension. Linear sulci were more heritable and typically located in unimodal cortex; complex sulci were less heritable and typically located in heteromodal cortex. Aligning these results with an independent fetal brain MRI cohort (N=228; 21-36 gestational weeks), we found that linear sulci formed earlier, and the earliest and latest-forming sulci had the least between-adult variation. Using high-resolution maps of cortical gene expression, we found that linear sulcation is mechanistically underpinned by trans-sulcal gene expression gradients enriched for developmental processes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":395523,"datarank":0.23027957124780765,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.022335417079824036,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.022335417079824036,"corpus_percentile":38.106289162218616,"corpus_rank":8002,"citation_count":3,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8406,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232629,"name":"Petra E. Vértes","orcid":"0000-0002-0992-3210","position":1,"is_corresponding":false},{"id":1115389,"name":"Vanessa Kyriakopoulou","orcid":"0000-0002-9883-0314","position":2,"is_corresponding":false},{"id":52275,"name":"Konrad Wagstyl","orcid":"0000-0003-3439-5808","position":3,"is_corresponding":false},{"id":815062,"name":"Logan Z. J. Williams","orcid":"0000-0001-5392-7043","position":4,"is_corresponding":false},{"id":659934,"name":"Dustin Moraczewski","orcid":"0000-0002-0422-3135","position":5,"is_corresponding":false},{"id":343600,"name":"Adam G. Thomas","orcid":null,"position":6,"is_corresponding":false},{"id":250903,"name":"Vyacheslav Karolis","orcid":"0000-0003-2074-6910","position":7,"is_corresponding":false},{"id":52331,"name":"Jakob Seidlitz","orcid":"0000-0002-8164-7476","position":8,"is_corresponding":false},{"id":283085,"name":"Denis Rivière","orcid":"0000-0002-1902-2213","position":9,"is_corresponding":false},{"id":250900,"name":"Emma C. Robinson","orcid":"0000-0002-7886-3426","position":10,"is_corresponding":false},{"id":267994,"name":"Jean‐François Mangin","orcid":"0000-0002-1612-461X","position":11,"is_corresponding":false},{"id":232635,"name":"Armin Raznahan","orcid":"0000-0002-5622-1190","position":12,"is_corresponding":false},{"id":52341,"name":"Edward T. Bullmore","orcid":"0000-0002-8955-8283","position":13,"is_corresponding":false},{"id":515253,"name":"William E. Snyder","orcid":"0000-0001-8629-4633","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T01:19:22.857556Z","pmid":"38168226","pmcid":"PMC10760196","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}