{"doi":"10.1101/2023.12.12.23299845","title":"Elevated plasma matrix metalloproteinases associate with <i>Mycobacterium tuberculosis</i> blood stream infection and mortality in HIV-associated tuberculosis","abstract":"Abstract Mortality from HIV-associated tuberculosis (HIV-TB) is high, particularly among hospitalised patients. In 433 people living with HIV admitted to hospital with symptoms of TB, we investigated plasma matrix metalloproteinases (MMP) and matrix-derived biomarkers in relation to TB diagnosis, mortality and Mycobacterium tuberculosis ( Mtb) blood stream infection (BSI). Compared to other diagnoses, MMP-8 was elevated in confirmed TB and in Mtb -BSI, positively correlating with extracellular matrix breakdown products. Baseline MMP- 3, -7, -8, -10 and procollagen III N-terminal propeptide (PIIINP) associated with Mtb -BSI and 12-week mortality. These findings implicate MMP dysregulation in pathophysiology of advanced HIV-TB and support MMP inhibition as a host-directed therapeutic strategy for HIV- TB.","journal":"medRxiv","year":2023,"id":414969,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9621,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":292860,"name":"Charlotte Schutz","orcid":"0000-0001-8329-6158","position":1,"is_corresponding":false},{"id":292875,"name":"Amy Ward","orcid":"0000-0002-7725-6763","position":2,"is_corresponding":false},{"id":292857,"name":"David Barr","orcid":"0000-0002-2922-9381","position":3,"is_corresponding":false},{"id":260117,"name":"Charles Opondo","orcid":"0000-0001-8155-4117","position":4,"is_corresponding":false},{"id":371678,"name":"Muki Shey","orcid":"0000-0002-8776-4737","position":5,"is_corresponding":false},{"id":1197161,"name":"PT Elkington","orcid":null,"position":6,"is_corresponding":false},{"id":1196842,"name":"Krystan A. Wilkinson","orcid":"0000-0002-2921-6011","position":7,"is_corresponding":false},{"id":1197162,"name":"RJ Wilkinson","orcid":null,"position":8,"is_corresponding":false},{"id":292884,"name":"Graeme Meintjes","orcid":"0000-0003-1196-4414","position":9,"is_corresponding":false},{"id":266675,"name":"Naomi F. Walker","orcid":"0000-0002-3345-7694","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T01:22:08.814145Z","pmid":"38168355","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}