{"doi":"10.1101/2023.11.28.569095","title":"Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts","abstract":"This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. 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