{"doi":"10.1101/2023.11.21.568150","title":"Single-cell and spatial detection of senescent cells using DeepScence","abstract":"Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence is based on CoreScence, a senescence-associated gene set we curated that incorporates information from multiple published gene sets. We demonstrate that DeepScence can accurately identify senescent cells in single-cell gene expression data collected both in vitro and in vivo, as well as in spatial transcriptomics data generated by different platforms, substantially outperforming existing methods.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":390463,"datarank":0.4788962055943047,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.10616020812610458,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.10616020812610458,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":9,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9447,"is_data_producer":true,"deposit_databanks":{"Dryad":["10.5061/dryad.t4b8gtj34"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1162760,"name":"Beijie Ji","orcid":null,"position":1,"is_corresponding":false},{"id":552251,"name":"Runze Dong","orcid":"0000-0002-7294-3070","position":2,"is_corresponding":false},{"id":822295,"name":"Liangcai Gu","orcid":"0000-0002-8232-6025","position":3,"is_corresponding":false},{"id":432169,"name":"Cliburn Chan","orcid":"0000-0001-5901-6806","position":4,"is_corresponding":false},{"id":610962,"name":"Jichun Xie","orcid":"0000-0001-5905-6728","position":5,"is_corresponding":false},{"id":374868,"name":"Carolyn Glass","orcid":"0000-0002-8850-9906","position":6,"is_corresponding":false},{"id":1021184,"name":"Xiao‐Fan Wang","orcid":"0000-0002-2534-0410","position":7,"is_corresponding":false},{"id":239530,"name":"Andrew B. Nixon","orcid":"0000-0003-3971-2964","position":8,"is_corresponding":false},{"id":1018274,"name":"Zhicheng Ji","orcid":"0000-0002-4837-7240","position":9,"is_corresponding":false},{"id":1162759,"name":"Yilong Qu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:18:37.743462Z","pmid":"38045252","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}