{"doi":"10.1101/2023.11.20.567904","title":"Molecular regulation of retinal regeneration is context specific","abstract":"Abstract Many genes are known to regulate retinal regeneration following widespread tissue damage. Conversely, genes controlling regeneration following limited retinal cell loss, akin to disease conditions, are undefined. Combining a novel retinal ganglion cell (RGC) ablation-based glaucoma model, single cell omics, and rapid CRISPR/Cas9-based knockout methods to screen 100 genes, we identified 18 effectors of RGC regeneration kinetics. Surprisingly, 32 of 33 previously known/implicated regulators of retinal tissue regeneration were not required for RGC replacement; 7 knockouts accelerated regeneration, including sox2, olig2, and ascl1a . Mechanistic analyses revealed loss of ascl1a increased “fate bias”, the propensity of progenitors to produce RGCs. These data demonstrate plasticity and context-specificity in how genes function to control regeneration, insights that could help to advance disease-tailored therapeutics for replacing lost retinal cells. One sentence summary We discovered eighteen genes that regulate the regeneration of retinal ganglion cells in zebrafish.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":395391,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":710823,"name":"John Hageter","orcid":null,"position":1,"is_corresponding":false},{"id":413525,"name":"Thanh Hoang","orcid":"0000-0002-7666-3842","position":2,"is_corresponding":false},{"id":813022,"name":"Pin Lyu","orcid":"0000-0002-9996-826X","position":3,"is_corresponding":false},{"id":559270,"name":"Abigail V. 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Ackerley","orcid":"0000-0002-6188-9902","position":20,"is_corresponding":false},{"id":268678,"name":"Jiang Qian","orcid":"0000-0002-0476-3596","position":21,"is_corresponding":false},{"id":245623,"name":"Seth Blackshaw","orcid":"0000-0002-1338-8476","position":22,"is_corresponding":false},{"id":332235,"name":"Eric J. Horstick","orcid":"0000-0003-3846-7450","position":23,"is_corresponding":false},{"id":559279,"name":"Jeff S. 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