{"doi":"10.1101/2023.11.09.23298289","title":"HIV prevalence in transgender women and cisgender men who have sex with men in sub-Saharan Africa 2010-2022: a meta-analysis","abstract":"Abstract Introduction The Global AIDS Strategy 2021-2026 calls for equitable access to HIV services for all populations. Transgender people have been marginalised and experience disproportionate risk of HIV infection in sub-Saharan Africa (SSA) and data to guide HIV programmes are severely limited. Surveillance data among cisgender men who have sex with men (cis-MSM) are comparatively abundant. We assessed whether HIV prevalence among cis-MSM was correlated with HIV prevalence among transgender women. Methods Data from key population surveys conducted in SSA between 2010-2022 were identified from existing databases and survey reports. Studies that collected HIV prevalence on both transgender women and cis-MSM populations were analysed with random effect meta-analysis to estimate the ratio of HIV prevalence among cis-MSM:transgender women. Results Twenty-one studies were identified encompassing 8,476 transgender women and 24,102 cis-MSM. Median HIV prevalence among transgender women was 23.5% (interquartile range [IQR] 11.5-39.8%) and 16.2% (IQR 8.1-26.8%) among cis-MSM. HIV prevalence among transgender women was 50% higher than in cis-MSM (prevalence ratio 1.48 95CI 1.25-1.76). HIV prevalence among transgender women was highly correlated with year/province-matched HIV prevalence among cis-MSM (R 2 =0.60), but poorly correlated with year/province-matched total population HIV prevalence (R 2 =0.01). Conclusion Transgender women experience a significantly greater HIV burden than cis-MSM in SSA, underscoring the need for HIV services addressing the disproportionate vulnerability experienced by transgender women. Further bio-behavioural surveys focused on determinants of HIV infection, treatment uptake, and risk behaviours among transgender people, distinct from cis-MSM, will improve understanding of HIV risk and vulnerabilities.","journal":"medRxiv","year":2023,"id":395342,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.835,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":40932,"name":"Rebecca L. Anderson","orcid":"0009-0002-6127-3769","position":1,"is_corresponding":false},{"id":289423,"name":"Keith Sabin","orcid":"0000-0002-2290-8621","position":2,"is_corresponding":false},{"id":1170618,"name":"Sonia Arias Garcia","orcid":"0000-0001-9402-8765","position":3,"is_corresponding":false},{"id":1170619,"name":"Elizabeth Fearon","orcid":"0000-0001-5574-251X","position":4,"is_corresponding":false},{"id":1170981,"name":"Kingsley Manda","orcid":null,"position":5,"is_corresponding":false},{"id":802324,"name":"Wame Dikobe","orcid":null,"position":6,"is_corresponding":false},{"id":415447,"name":"Lloyd Mulenga","orcid":"0000-0002-1044-4209","position":7,"is_corresponding":false},{"id":921656,"name":"Neena M. Philip","orcid":"0000-0001-5816-8197","position":8,"is_corresponding":false},{"id":447706,"name":"Mathieu Maheu‐Giroux","orcid":"0000-0002-8363-4388","position":9,"is_corresponding":false},{"id":341683,"name":"Jinkou Zhao","orcid":"0000-0001-9184-3385","position":10,"is_corresponding":false},{"id":625936,"name":"Mary Mahy","orcid":"0000-0001-6023-3023","position":11,"is_corresponding":false},{"id":1170982,"name":"Jeffrey W. Imai-Eaton","orcid":null,"position":12,"is_corresponding":false},{"id":1079524,"name":"Oliver Stevens","orcid":"0000-0001-6842-9434","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:19:22.857556Z","pmid":"37986978","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}