{"doi":"10.1101/2023.10.27.23297697","title":"Olfactory impairment and the risk of major adverse cardiovascular outcomes in older adults","abstract":"Background: Olfactory impairment is common in older adults and may be associated with adverse cardiovascular health; however, empirical evidence is sparse. Objective: To examine olfaction and the risk of coronary heart disease (CHD), stroke, and congestive heart failure (CHF). Methods: This study included 2,537 older adults (aged 75.6±2.8 years) from the Health ABC Study with olfaction assessed by the 12-item Brief Smell Identification Test in 1999-2000, defined as poor (score ≤8), moderate (9-10), or good (11-12). The outcomes were incident CHD, stroke, and CHF. Results: During up to 12-year follow-up, 353 incident CHD, 258 stroke, and 477 CHF events were identified. Olfaction was associated with incident CHF, but not with CHD or stroke. After adjusting for demographics, the cause-specific hazard ratio (HR) of CHF was 1.35 (95% confidence interval (CI): 1.08, 1.70) for moderate and 1.39 (95%CI: 1.09, 1.76) for poor olfaction. With additional adjustment for lifestyle, chronic diseases, and biomarkers of CHF, the HR was modestly attenuated to 1.32 (95%CI: 1.05, 1.66) for moderate and 1.28 (95%CI: 1.01, 1.64) for poor olfaction. These associations were robust in pre-planned subgroup analyses by age, sex, race, and prevalent CHD/stroke. However, the associations appeared to be evident among participants who reported very-good-to-excellent health (HR=1.47 (95%CI: 1.02, 2.13) for moderate and 1.76, (95%CI: 1.20, 2.57) for poor olfaction). In contrast, null association with CHF was found among those with fair-to-poor self-reported health. Conclusions: In community-dwelling older adults, a single olfaction test was associated with a long-term risk for incident CHF, particularly among those reporting very-good-to-excellent health.","journal":"medRxiv","year":2023,"id":395294,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8899,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":704842,"name":"Yaqun Yuan","orcid":"0000-0002-9825-7474","position":1,"is_corresponding":false},{"id":612714,"name":"Chenxi Li","orcid":"0000-0003-0701-0757","position":2,"is_corresponding":false},{"id":396356,"name":"Zhehui Luo","orcid":"0000-0001-9193-3380","position":3,"is_corresponding":false},{"id":74987,"name":"Mathew J. Reeves","orcid":"0000-0002-8019-6343","position":4,"is_corresponding":false},{"id":402436,"name":"Anna Kucharska‐Newton","orcid":"0000-0001-9864-467X","position":5,"is_corresponding":false},{"id":326655,"name":"Jayant M. Pinto","orcid":"0000-0003-2838-490X","position":6,"is_corresponding":false},{"id":291135,"name":"Jiantao Ma","orcid":"0000-0001-7478-7203","position":7,"is_corresponding":false},{"id":264194,"name":"Eleanor M. Simonsick","orcid":"0000-0002-5460-3494","position":8,"is_corresponding":false},{"id":292088,"name":"Honglei Chen","orcid":"0000-0003-3446-7779","position":9,"is_corresponding":false},{"id":1140658,"name":"Keran W. Chamberlin","orcid":"0000-0003-4721-4316","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T01:19:18.686170Z","pmid":"37961698","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}