{"doi":"10.1101/2023.10.21.563408","title":"Parietal stimulation reverses age-related decline in exploration, learning, and decision-making","abstract":"Aging can compromise decision-making and learning, potentially due to reduced exploratory behaviors crucial for novel problem-solving. We posit that invigorating exploration could mitigate these declines. Supporting this hypothesis, we found that older mice mirrored human aging, displaying less exploration and learning during decision-making, but optogenetic stimulation of their posterior parietal cortex boosted initial exploration, subsequently improving learning. Thus, enhancing exploration-driven learning could be a key to countering cognitive aging.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":397559,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9466,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1173797,"name":"Sayli Korde","orcid":null,"position":1,"is_corresponding":false},{"id":267079,"name":"Ying Han","orcid":"0000-0003-0377-7424","position":2,"is_corresponding":false},{"id":280193,"name":"Jaydeep Sambangi","orcid":null,"position":3,"is_corresponding":false},{"id":1173798,"name":"Bowen Lian","orcid":null,"position":4,"is_corresponding":false},{"id":1173799,"name":"Ama Owusu-Ofori","orcid":null,"position":5,"is_corresponding":false},{"id":1173800,"name":"Megi Diasamidze","orcid":null,"position":6,"is_corresponding":false},{"id":1173801,"name":"Lea M. Wong","orcid":null,"position":7,"is_corresponding":false},{"id":1173802,"name":"Nadine Pickering","orcid":null,"position":8,"is_corresponding":false},{"id":1173803,"name":"Sam Begin","orcid":null,"position":9,"is_corresponding":false},{"id":656878,"name":"Eun Jung Hwang","orcid":"0000-0003-2786-5963","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:19:39.497368Z","pmid":"37970542","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}