{"doi":"10.1101/2023.10.09.561580","title":"Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation","abstract":"The hippocampus (HPC), traditionally known for its role in learning and memory, has emerged as a controller of food intake. While prior studies primarily associated the HPC with food intake inhibition, recent research suggests a critical role in appetitive processes. We hypothesized that orexigenic HPC neurons differentially respond to fats and/or sugars, potent natural reinforcers that contribute to obesity development. Results uncover previously-unrecognized, spatially-distinct neuronal ensembles within the dorsal HPC (dHPC) that are responsive to separate nutrient signals originating from the gut. Using activity-dependent genetic capture of nutrient-responsive HPC neurons, we demonstrate a causal role of both populations in promoting nutrient-specific preference through different mechanisms. Sugar-responsive neurons encode an appetitive spatial memory engram for meal location, whereas fat-responsive neurons selectively enhance the preference and motivation for fat intake. Collectively, these findings uncover a neural basis for the exquisite specificity in processing macronutrient signals from a meal that shape dietary choices.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":412524,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459451,"name":"Arashdeep Singh","orcid":"0000-0002-2477-1438","position":1,"is_corresponding":false},{"id":460404,"name":"Molly McDougle","orcid":null,"position":2,"is_corresponding":false},{"id":862940,"name":"Léa Décarie-Spain","orcid":"0000-0001-6599-7102","position":3,"is_corresponding":false},{"id":235898,"name":"Scott E. Kanoski","orcid":"0000-0001-9526-206X","position":4,"is_corresponding":false},{"id":288451,"name":"Guillaume de Lartigue","orcid":"0000-0002-0032-8810","position":5,"is_corresponding":false},{"id":985410,"name":"Mingxin Yang","orcid":"0000-0003-1744-5607","position":0,"is_corresponding":true}],"reference_count":151,"raw_metadata":null,"created_at":"2026-07-19T01:21:50.261851Z","pmid":"37873148","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}