{"doi":"10.1101/2023.10.07.561364","title":"Transcription machinery clustering by Integrator synchronizes histone gene expression","abstract":"Abstract Numerous components of the transcription machinery, including RNA polymerase II (Pol II), accumulate in high-concentration clusters at promoters. Whether these clusters assemble on demand during transcription or constitute regulatory units remains unclear. Examining the Drosophila histone locus—where histone genes are transcribed exclusively during S phase—we unexpectedly found large clusters containing non-chromatin-bound Pol II and elongation factors outside S phase. When transcription is activated during S phase, P-TEFb drives accelerated turnover of cluster components. Dispersion of clusters through depletion of the Integrator complex endonuclease module causes histone transcription to have a diminished S-phase peak and instead occur ectopically throughout the cell cycle. We propose that clusters act as gatekeeping hubs by maintaining a poised machinery pool, thereby restricting gene activation to defined temporal windows.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":391518,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1004888,"name":"B. Park","orcid":null,"position":1,"is_corresponding":false},{"id":816455,"name":"Rina Fujiwara","orcid":"0000-0003-0076-0029","position":2,"is_corresponding":false},{"id":233161,"name":"Jeremy E. Wilusz","orcid":"0000-0001-6929-8755","position":3,"is_corresponding":false},{"id":649505,"name":"David S. Gilmour","orcid":"0000-0003-4665-6147","position":4,"is_corresponding":false},{"id":63535,"name":"Ruth Lehmann","orcid":"0000-0002-8454-5651","position":5,"is_corresponding":false},{"id":241454,"name":"Timothée Lionnet","orcid":"0000-0003-1508-0202","position":6,"is_corresponding":false},{"id":1164730,"name":"Feiyue Lu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-19T01:18:47.408273Z","pmid":"37873455","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}