{"doi":"10.1101/2023.10.04.560979","title":"Multimodal joint deconvolution and integrative signature selection in proteomics","abstract":"Abstract Deconvolution is an efficient approach for detecting cell-type-specific (cs) transcriptomic signals without cellular segmentation. However, this type of methods have not been extended to the proteomics research. Here we present a novel algorithm and tool to dissect bulk proteome by leveraging the information shared between transcriptome-proteome. Our tool first identifies potential cell marker proteins by integrating RNA and protein bulk expression profiles and then jointly quantifies the cell abundance in mixture proteomes without using a reference signature matrix, enabling the downstream analyses such as cs-protein Quantitative Trait Loci (cspQTL) mapping. This new method and the cspQTL analysis are implemented in the R package MIC-SQTL that also provides integrative visualization of bulk multimodal samples, available at https://bioconductor.org/packages/MICSQTL .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":412442,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":97163,"name":"Xusheng Wang","orcid":"0000-0002-1759-9588","position":1,"is_corresponding":false},{"id":21434,"name":"Chunyu Liu","orcid":"0000-0002-5986-4415","position":2,"is_corresponding":false},{"id":97162,"name":"Junmin Peng","orcid":"0000-0003-0472-7648","position":3,"is_corresponding":false},{"id":342448,"name":"Qian Li","orcid":"0000-0001-9874-3555","position":4,"is_corresponding":false},{"id":776314,"name":"Yue Pan","orcid":"0000-0003-1958-2744","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T01:21:50.261851Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}