{"doi":"10.1101/2023.09.27.23296169","title":"Striatal dopamine tone is positively associated with body mass index in humans as determined by PET using dual dopamine type-2 receptor antagonist tracers","abstract":"ABSTRACT The relationship between adiposity and dopamine type-2 receptor binding potential (D2BP) in the human brain has been repeatedly studied for >20 years with highly discrepant results, likely due to variable methodologies and differing study populations. We conducted a controlled inpatient feeding study to measure D2BP in the striatum using positron emission tomography with both [ 18 F]fallypride and [ 11 C]raclopride in pseudo-random order in 54 young adults with a wide range of body mass index (BMI 20-44 kg/m 2 ). Within-subject D2BP measurements using the two tracers were moderately correlated (r=0.47, p<0.001). D2BP was negatively correlated with BMI as measured by [ 11 C]raclopride (r= -0.51; p<0.0001) but not [ 18 F]fallypride (r=-0.01; p=0.92) and these correlation coefficients were significantly different from each other (p<0.001). Given that [ 18 F]fallypride has greater binding affinity to dopamine type-2 receptors than [ 11 C]raclopride, which is more easily displaced by endogenous dopamine, our results suggest that adiposity is positively associated with increased striatal dopamine tone.","journal":"medRxiv","year":2023,"id":390594,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251342,"name":"Juen Guo","orcid":"0000-0003-2876-5884","position":1,"is_corresponding":false},{"id":1162862,"name":"Meible Chi","orcid":null,"position":2,"is_corresponding":false},{"id":270254,"name":"Stephanie T. Chung","orcid":"0000-0001-6989-0417","position":3,"is_corresponding":false},{"id":270255,"name":"Amber B. Courville","orcid":"0000-0002-1419-3937","position":4,"is_corresponding":false},{"id":621513,"name":"Isabelle Gallagher","orcid":"0000-0003-1686-2134","position":5,"is_corresponding":false},{"id":234134,"name":"Peter Herscovitch","orcid":null,"position":6,"is_corresponding":false},{"id":277423,"name":"Rebecca Howard","orcid":"0009-0004-7709-6167","position":7,"is_corresponding":false},{"id":1162863,"name":"Melissa LaNoire","orcid":null,"position":8,"is_corresponding":false},{"id":621514,"name":"Lauren Milley","orcid":"0009-0006-0449-2315","position":9,"is_corresponding":false},{"id":621515,"name":"Alex Schick","orcid":"0000-0003-3015-9138","position":10,"is_corresponding":false},{"id":272692,"name":"Michael Stagliano","orcid":null,"position":11,"is_corresponding":false},{"id":1103797,"name":"Sara Turner","orcid":null,"position":12,"is_corresponding":false},{"id":1162864,"name":"Nicholas Urbanski","orcid":null,"position":13,"is_corresponding":false},{"id":272693,"name":"Shanna Yang","orcid":null,"position":14,"is_corresponding":false},{"id":1162865,"name":"Eunha Yim","orcid":null,"position":15,"is_corresponding":false},{"id":1162866,"name":"Nan Zhai","orcid":null,"position":16,"is_corresponding":false},{"id":270260,"name":"Megan Zhou","orcid":"0000-0002-9199-0358","position":17,"is_corresponding":false},{"id":251344,"name":"Kevin D. Hall","orcid":"0000-0003-4062-3133","position":18,"is_corresponding":false},{"id":270256,"name":"Valerie L. Darcey","orcid":"0000-0002-5053-4567","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:18:37.743462Z","pmid":"37886556","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}