{"doi":"10.1101/2023.09.25.23296088","title":"Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study","abstract":"<jats:title>Abstract</jats:title>\n                <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and its exacerbators require further investigation.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>We studied centrum semiovale (CSO) and basal ganglia (BG) PVS computationally over three to four annual visits in 557 participants of the DZNE multicentre DELCODE cohort. We tested volumetric changes of PVS in relation to ageing, sex, years of education, hypertension, AD diagnosis, and cerebrospinal-fluid-derived Amyloid and Tau positivity and interleukin 6 (IL-6).</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>PVS volumes increased over time. PVS enlargement was associated with baseline white matter hyperintensities. BG-PVS enlargement was related to age and was faster with hypertension. CSO-PVS volumes increased faster with Amyloid and Tau positivity. Higher CSF IL-6 levels predicted PVS volume expansion in both regions and were associated with accelerated PVS enlargement in individuals with Amyloid and Tau positivity.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion</jats:title>\n                  <jats:p>Our work supports the region-specific involvement of white matter hyperintensities, neurotoxic waste accumulation, and inflammation in PVS enlargement.</jats:p>\n                </jats:sec>","journal":null,"year":null,"id":615330,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1585935,"name":"Jose Bernal","orcid":null,"position":1,"is_corresponding":false},{"id":1585937,"name":"Pinar Kaya","orcid":null,"position":2,"is_corresponding":false},{"id":1585938,"name":"Çağla Aki","orcid":null,"position":3,"is_corresponding":false},{"id":1585940,"name":"Malte Pfister","orcid":null,"position":4,"is_corresponding":false},{"id":1585941,"name":"Jonas Geisendörfer","orcid":null,"position":5,"is_corresponding":false},{"id":744632,"name":"Renat Yakupov","orcid":"0000-0002-3868-284X","position":6,"is_corresponding":false},{"id":225475,"name":"Michael T. Heneka","orcid":"0000-0003-4996-1630","position":7,"is_corresponding":false},{"id":647716,"name":"Frederic Brosseron","orcid":"0000-0003-3137-7516","position":8,"is_corresponding":false},{"id":1585945,"name":"Matthias C. Schmid","orcid":null,"position":9,"is_corresponding":false},{"id":790809,"name":"Wenzel Glanz","orcid":"0000-0002-5865-4176","position":10,"is_corresponding":false},{"id":67313,"name":"Enise I. Incesoy","orcid":null,"position":11,"is_corresponding":false},{"id":1378949,"name":"Michaela Butryn","orcid":null,"position":12,"is_corresponding":false},{"id":1096093,"name":"Ayda Rostamzadeh","orcid":"0000-0001-5189-134X","position":13,"is_corresponding":false},{"id":623985,"name":"Dix Meiberth","orcid":"0000-0002-4348-0724","position":14,"is_corresponding":false},{"id":67316,"name":"Oliver Peters","orcid":null,"position":15,"is_corresponding":false},{"id":790811,"name":"Lukas Preis","orcid":"0000-0001-7601-6410","position":16,"is_corresponding":false},{"id":1585959,"name":"Dominik Lammerding","orcid":null,"position":17,"is_corresponding":false},{"id":1124963,"name":"Daria Gref","orcid":null,"position":18,"is_corresponding":false},{"id":554056,"name":"Josef Priller","orcid":"0000-0001-7596-0979","position":19,"is_corresponding":false},{"id":1585964,"name":"Eike J. Spruth","orcid":null,"position":20,"is_corresponding":false},{"id":790806,"name":"Slawek Altenstein","orcid":"0000-0003-2753-5999","position":21,"is_corresponding":false},{"id":1124965,"name":"Andrea Lohse","orcid":null,"position":22,"is_corresponding":false},{"id":1175097,"name":"Stefan Hetzer","orcid":"0000-0002-1773-1518","position":23,"is_corresponding":false},{"id":1212282,"name":"Anja Schneider","orcid":"0009-0004-9225-1145","position":24,"is_corresponding":false},{"id":1585971,"name":"Klaus Fliessbach","orcid":null,"position":25,"is_corresponding":false},{"id":1206973,"name":"Okka Kimmich","orcid":"0009-0008-2119-7590","position":26,"is_corresponding":false},{"id":1585973,"name":"Ina R. Vogt","orcid":null,"position":27,"is_corresponding":false},{"id":473736,"name":"Jens Wiltfang","orcid":"0000-0003-1492-5330","position":28,"is_corresponding":false},{"id":647715,"name":"Claudia Bartels","orcid":"0000-0003-3023-9971","position":29,"is_corresponding":false},{"id":790812,"name":"Björn H. Schott","orcid":"0000-0002-8237-4481","position":30,"is_corresponding":false},{"id":971308,"name":"Niels Hansen","orcid":"0000-0003-4366-6120","position":31,"is_corresponding":false},{"id":744628,"name":"Peter Dechent","orcid":"0009-0006-4005-3352","position":32,"is_corresponding":false},{"id":84327,"name":"Katharina Buerger","orcid":null,"position":33,"is_corresponding":false},{"id":647719,"name":"Daniel Janowitz","orcid":"0009-0003-4090-547X","position":34,"is_corresponding":false},{"id":7728,"name":"Robert Perneczky","orcid":"0000-0003-1981-7435","position":35,"is_corresponding":false},{"id":84318,"name":"Boris-Stephan Rauchmann","orcid":null,"position":36,"is_corresponding":false},{"id":312311,"name":"Stefan Teipel","orcid":"0000-0002-3586-3194","position":37,"is_corresponding":false},{"id":67681,"name":"Ingo Kilimann","orcid":null,"position":38,"is_corresponding":false},{"id":1585984,"name":"Doreen Goerss","orcid":null,"position":39,"is_corresponding":false},{"id":1308338,"name":"Christoph Laske","orcid":"0009-0009-3434-936X","position":40,"is_corresponding":false},{"id":647721,"name":"Matthias H. Munk","orcid":"0000-0002-5339-4045","position":41,"is_corresponding":false},{"id":1585988,"name":"Carolin Sanzenbacher","orcid":null,"position":42,"is_corresponding":false},{"id":1585990,"name":"Petra Hinderer","orcid":null,"position":43,"is_corresponding":false},{"id":384838,"name":"Klaus Scheffler","orcid":"0000-0001-6316-8773","position":44,"is_corresponding":false},{"id":588066,"name":"Annika Spottke","orcid":"0000-0001-9854-2972","position":45,"is_corresponding":false},{"id":1585994,"name":"Nina Roy-Kluth","orcid":null,"position":46,"is_corresponding":false},{"id":543140,"name":"Falk Lüsebrink","orcid":null,"position":47,"is_corresponding":false},{"id":1585997,"name":"Katja Neumann","orcid":null,"position":48,"is_corresponding":false},{"id":67836,"name":"Frank Jessen","orcid":null,"position":49,"is_corresponding":false},{"id":839066,"name":"Stefanie Schreiber","orcid":"0000-0003-4439-4374","position":50,"is_corresponding":false},{"id":550561,"name":"Emrah Düzel","orcid":"0000-0002-0139-5388","position":51,"is_corresponding":false},{"id":1058400,"name":"Gabriel Ziegler","orcid":"0000-0001-6589-6416","position":52,"is_corresponding":false},{"id":1585934,"name":"Inga Menze","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study","abstract":"<jats:title>Abstract</jats:title>\n                <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and its exacerbators require further investigation.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>We studied centrum semiovale (CSO) and basal ganglia (BG) PVS computationally over three to four annual visits in 557 participants of the DZNE multicentre DELCODE cohort. We tested volumetric changes of PVS in relation to ageing, sex, years of education, hypertension, AD diagnosis, and cerebrospinal-fluid-derived Amyloid and Tau positivity and interleukin 6 (IL-6).</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>PVS volumes increased over time. PVS enlargement was associated with baseline white matter hyperintensities. BG-PVS enlargement was related to age and was faster with hypertension. CSO-PVS volumes increased faster with Amyloid and Tau positivity. Higher CSF IL-6 levels predicted PVS volume expansion in both regions and were associated with accelerated PVS enlargement in individuals with Amyloid and Tau positivity.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion</jats:title>\n                  <jats:p>Our work supports the region-specific involvement of white matter hyperintensities, neurotoxic waste accumulation, and inflammation in PVS enlargement.</jats:p>\n                </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W4387036417","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.medrxiv.org/content/medrxiv/early/2023/09/26/2023.09.25.23296088.full.pdf","host_type":"repository"},{"url":"https://www.medrxiv.org/content/medrxiv/early/2023/09/26/2023.09.25.23296088.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2023.09.25.23296088","host_type":"publisher"},{"url":"https://doi.org/10.1101/2023.09.25.23296088","host_type":"repository"}],"fields_of_study":["Cerebrospinal fluid and hydrocephalus","Spinal Dysraphism and Malformations","Fetal and Pediatric Neurological Disorders"],"mesh_terms":[],"keywords":["Hyperintensity","Perivascular space","White matter","Medicine","Pathology","Inflammation","Cerebrospinal fluid","Cognitive decline","Magnetic resonance imaging","Internal medicine","Cardiology","Disease","Radiology","Dementia"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T19:42:35.030898Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}