{"doi":"10.1101/2023.09.14.557801","title":"Diverse Plant-Parasitic Nematodes are Selectively Killed by Oxadiazole Thioether Pro-Nematicides","abstract":"ABSTRACT Left unchecked, plant-parasitic nematodes have the potential to devastate crops globally. Highly effective but non-selective nematicides are justifiably being phased-out, leaving farmers with limited options for managing nematode infestation. Here, we report our discovery of a 1,3,4-oxadiazole thioether scaffold called Cyprocide that selectively kills diverse plant-parasitic nematodes. Cyprocide is bioactivated into a lethal reactive electrophilic metabolite by specific nematode cytochrome P450 enzymes. Because Cyprocide fails to kill non-target organisms, we infer that the targeted lethality of this pro-nematicide derives from P450 substrate selectivity. Our findings demonstrate that Cyprocide is a selective nematicidal scaffold with broad-spectrum activity that holds the potential to help safeguard our global food supply.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":411514,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1001160,"name":"Andrew R. Burns","orcid":"0000-0002-8966-1280","position":1,"is_corresponding":false},{"id":1094268,"name":"Brittany Cooke","orcid":"0000-0002-6386-1655","position":2,"is_corresponding":false},{"id":1192235,"name":"Savina R. Cammalleri","orcid":null,"position":3,"is_corresponding":false},{"id":1192236,"name":"Megan Kitner","orcid":null,"position":4,"is_corresponding":false},{"id":1079000,"name":"Justin Ching","orcid":"0000-0002-2511-216X","position":5,"is_corresponding":false},{"id":1191927,"name":"Jack M.P. Castelli","orcid":"0000-0001-5834-0620","position":6,"is_corresponding":false},{"id":344686,"name":"Emily Puumala","orcid":"0009-0008-3371-5877","position":7,"is_corresponding":false},{"id":389181,"name":"Jamie Snider","orcid":"0000-0001-5647-3729","position":8,"is_corresponding":false},{"id":663138,"name":"Emily Koury","orcid":"0000-0001-7869-504X","position":9,"is_corresponding":false},{"id":945328,"name":"James B. Collins","orcid":"0000-0003-0808-5216","position":10,"is_corresponding":false},{"id":290047,"name":"Erik C. Andersen","orcid":"0000-0003-0229-9651","position":11,"is_corresponding":false},{"id":389184,"name":"Igor Štagljar","orcid":"0000-0002-5260-3327","position":12,"is_corresponding":false},{"id":308244,"name":"Leah E. Cowen","orcid":"0000-0001-5797-0110","position":13,"is_corresponding":false},{"id":1055005,"name":"Mark Lautens","orcid":"0000-0002-0179-2914","position":14,"is_corresponding":false},{"id":1042613,"name":"Inga A. Zasada","orcid":"0000-0001-6603-3073","position":15,"is_corresponding":false},{"id":583539,"name":"Peter J. Roy","orcid":"0000-0003-2959-2276","position":16,"is_corresponding":false},{"id":583538,"name":"Jessica Knox","orcid":"0000-0003-1465-5852","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:21:42.971455Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}