{"doi":"10.1101/2023.08.21.554224","title":"A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in <i>Caenorhabditis elegans</i>","abstract":"Abstract While depolarization of neuronal membrane is known to evoke the neurotransmitter release from synaptic vesicles, hyperpolarization is regarded as a resting state of chemical neurotransmission. Here we report that hyperpolarizing neurons can actively signal neural information by employing undocked hemichannels. We show that UNC-7, a member of the innexin family in Caenorhabditis elegans, functions as a hemichannel in thermosensory neurons and transmits temperature information from the thermosensory neurons to their post-synaptic interneurons. By monitoring neural activities in freely behaving animals, we find that hyperpolarizing thermosensory neurons inhibit the activity of the interneurons and that UNC-7 hemichannels regulate this process. UNC-7 is required to control thermotaxis behavior and functions independently of synaptic vesicle exocytosis. Our findings suggest that innexin hemichannels mediate neurotransmission from hyperpolarizing neurons in a manner that is distinct from the synaptic transmission, expanding the way of neural circuitry operations.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":410667,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":56697,"name":"Masakatsu Watanabe","orcid":"0000-0002-5744-197X","position":1,"is_corresponding":false},{"id":952308,"name":"Riku Yamashiro","orcid":"0000-0002-2816-9014","position":2,"is_corresponding":false},{"id":958674,"name":"Hiroo Kuroyanagi","orcid":"0000-0002-5382-8659","position":3,"is_corresponding":false},{"id":1190578,"name":"Atsunori Oshima","orcid":"0000-0003-1174-1368","position":4,"is_corresponding":false},{"id":490866,"name":"Ikue Mori","orcid":"0000-0003-2116-8825","position":5,"is_corresponding":false},{"id":571506,"name":"Shunji Nakano","orcid":"0000-0002-6565-9450","position":6,"is_corresponding":false},{"id":958673,"name":"Airi Nakayama","orcid":"0000-0002-9810-2106","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:21:35.071397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}