{"doi":"10.1101/2023.08.17.553682","title":"Central and peripheral tau retention modulated by an anti-tau antibody","abstract":"Tau protein blood levels dependent on its distribution to peripheral organs and possible elimination from the body. Thus, the peripheral distribution of CSF-derived tau protein was explored, especially since there is a transition to blood-based biomarkers and the emerging idea that tau pathology may spread beyond brain. Near infrared fluorescence (NIRF) was mainly used to analyze tau (tau-NIRF) distribution after its intracisternal or intravenous injection. There was a striking uptake of blood- or CSF-derived tau-NIRF protein by the skeletal structures, liver, small intestine (duodenum), gall bladder, kidneys, urinary bladder, lymph nodes, heart, and spleen. In aging and in older APP/PS1 mice, tau uptake in regions, such as the brain, liver, and skeleton, was increased. In bone (femur) injected tau protein was associated with integrin-binding sialoprotein (IBSP), a major non-collagenous glycoprotein that is associated with mineralization. Tau-NIRF was cleared slowly from CSF via mainly across the cribriform plate, and cervical lymph nodes. In brain, some of the CSF injected tau protein was associated with NeuN-positive and PDGFRý-positive cells, which may explain its retention. The presence of tau in the bladders suggested excretion routes of tau. CSF anti-tau antibody increased CSF tau clearance, while blood anti-tau antibody decreased tau accumulation in the femur but not in liver, kidney, and spleen. Thus, the data show a body-wide distribution and retention of CSF-derived tau protein, which increased with aging and in older APP/PS1 mice. Further work is needed to elucidate the relevance of tau accumulation in each organ to tauopathy.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394985,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":648343,"name":"Molly Brady","orcid":"0000-0003-2022-6042","position":1,"is_corresponding":false},{"id":236486,"name":"Nemil Bhatt","orcid":"0000-0001-5017-7312","position":2,"is_corresponding":false},{"id":700056,"name":"Angelique Johnson","orcid":null,"position":3,"is_corresponding":false},{"id":1170330,"name":"Brooke Burgess","orcid":null,"position":4,"is_corresponding":false},{"id":821422,"name":"Hannah Leyva","orcid":"0000-0002-5489-6987","position":5,"is_corresponding":false},{"id":264065,"name":"Nicha Puangmalai","orcid":"0000-0002-1138-237X","position":6,"is_corresponding":false},{"id":857843,"name":"Cynthia Jerez","orcid":"0009-0002-2678-1127","position":7,"is_corresponding":false},{"id":449538,"name":"Ronald W. Wood","orcid":"0000-0002-9691-5111","position":8,"is_corresponding":false},{"id":236490,"name":"Rakez Kayed","orcid":"0000-0001-6216-8640","position":9,"is_corresponding":false},{"id":648344,"name":"Rashid Deane","orcid":"0000-0002-0202-3551","position":10,"is_corresponding":false},{"id":821421,"name":"Alexander Solorzano","orcid":"0000-0002-3700-9135","position":0,"is_corresponding":true}],"reference_count":113,"raw_metadata":null,"created_at":"2026-07-19T01:19:18.686170Z","pmid":"37645819","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}