{"doi":"10.1101/2023.08.08.552438","title":"TMEM165 acts as a proton-activated Ca <sup>2+</sup> importer in lysosomes","abstract":"Summary Lysosomal calcium (Ca 2+ ) release is critical to cell signaling and is mediated by well-known lysosomal Ca 2+ channels. Yet, how lysosomes refill their Ca 2+ remains hitherto undescribed. Here, from an RNAi screen, we identify an evolutionarily conserved gene, lci-1 , that facilitates lysosomal Ca 2+ entry in C. elegans and in mammalian cells. Its human homolog TMEM165, previously designated as a Golgi-resident Ca 2+ /H + exchanger (CAX), has a minor lysosomal population of unknown function. Using genetics, lysosomal Ca 2+ imaging and electrophysiology, we show that TMEM165 acts as a proton-activated, lysosomal C a 2+ importer in lysosomes. Defects in lysosomal Ca 2+ channels cause several neurodegenerative diseases, and knowledge of lysosomal Ca 2+ importers may provide new avenues to explore the physiology of Ca 2+ channels.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":400384,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1176899,"name":"Sourajit Mukherjee","orcid":"0000-0002-6561-6557","position":1,"is_corresponding":false},{"id":760929,"name":"Palapuravan Anees","orcid":"0000-0003-2118-8893","position":2,"is_corresponding":false},{"id":1035368,"name":"Daphne Oettinger","orcid":null,"position":3,"is_corresponding":false},{"id":1177281,"name":"Katharine Henn","orcid":null,"position":4,"is_corresponding":false},{"id":1177282,"name":"Jainaha Srikumar","orcid":null,"position":5,"is_corresponding":false},{"id":1034908,"name":"Junyi Zou","orcid":"0000-0001-5005-737X","position":6,"is_corresponding":false},{"id":559618,"name":"Anand Saminathan","orcid":"0000-0002-9225-5558","position":7,"is_corresponding":false},{"id":457283,"name":"Yamuna Krishnan","orcid":"0000-0001-5282-8852","position":8,"is_corresponding":false},{"id":457279,"name":"Matthew Zajac","orcid":"0000-0001-8282-2160","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:20:04.010538Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}