{"doi":"10.1101/2023.08.07.552290","title":"Activity-dependent Mitochondrial ROS Signaling Regulates Recruitment of Glutamate Receptors to Synapses","abstract":"SUMMARY Our understanding of mitochondrial signaling in the nervous system has been limited by the technical challenge of analyzing mitochondrial function in vivo . In the transparent genetic model Caenorhabditis elegans, we were able to manipulate and measure mitochondrial signaling as well as neuronal activity in vivo . Using this approach, we provide evidence supporting a novel role for mitochondrial signaling in dendrites. Specifically, we show that dendritic mitochondria take up calcium (Ca 2+ ) via the mitochondrial Ca 2+ uniporter MCU-1 causing an upregulation of mitochondrial reactive oxygen species (mitoROS) production. We also observed that mitochondria are positioned in close proximity to synaptic clusters of GLR-1, the C. elegans ortholog of the AMPA subtype of glutamate receptors that mediate neuronal excitation. We show that synaptic recruitment of GLR-1 is downregulated by mitoROS signaling resulting from mitochondrial Ca 2+ uptake via MCU-1. Thus, postsynaptic mitochondria provide a means of negative feedback that regulates excitatory synapse function which may be vital for neuronal homeostasis by preventing excitotoxicity and energy depletion.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":396998,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9468,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":437374,"name":"Kaz M. Knight","orcid":"0000-0002-3184-3620","position":1,"is_corresponding":false},{"id":1123491,"name":"Ennis W. Deihl","orcid":"0009-0003-6737-8964","position":2,"is_corresponding":false},{"id":494511,"name":"Frédéric J. Hoerndli","orcid":"0000-0001-6838-0386","position":3,"is_corresponding":false},{"id":424692,"name":"Rachel L. Doser","orcid":"0000-0001-9057-4371","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:19:35.497854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}