{"doi":"10.1101/2023.07.25.550452","title":"Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin","abstract":"Abstract Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here we show that early-life thermal stress strongly up-regulates tsp-1 , a gene encoding the conserved transmembrane tetraspanin in C. elegans . TSP-1 forms prominent multimers and stable web- like structures critical for membrane barrier functions in adults and during aging. The up- regulation of TSP-1 persists even after transient early-life stress. Such regulation requires CBP- 1, a histone acetyl-transferase that facilitates initial tsp-1 transcription. Tetraspanin webs form regular membrane structures and mediate resilience-promoting effects of early-life thermal stress. Gain-of-function TSP-1 confers marked C. elegans longevity extension and thermal resilience in human cells. Together, our results reveal a cellular mechanism by which early-life thermal stress produces long-lasting memory-like impact on organismal resilience and longevity. Teaser Studies reveal mechanisms of how early-life heat exposure produces long-lasting benefits on longevity in the nematode C. elegans .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394865,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":986309,"name":"Henry De Belly","orcid":"0000-0003-2452-4450","position":1,"is_corresponding":false},{"id":577094,"name":"Bingying Wang","orcid":"0000-0001-7362-7371","position":2,"is_corresponding":false},{"id":1117022,"name":"Andrew Wong","orcid":"0000-0002-0902-3159","position":3,"is_corresponding":false},{"id":1169700,"name":"Minseo Kim","orcid":"0000-0002-8958-0720","position":4,"is_corresponding":false},{"id":871858,"name":"Fiona Oh","orcid":null,"position":5,"is_corresponding":false},{"id":1170235,"name":"Jason DeGeorge","orcid":null,"position":6,"is_corresponding":false},{"id":401462,"name":"Xinya Huang","orcid":"0009-0006-1077-1564","position":7,"is_corresponding":false},{"id":572372,"name":"Shouhong Guang","orcid":"0000-0001-7700-9634","position":8,"is_corresponding":false},{"id":656841,"name":"Orion D. Weiner","orcid":"0000-0002-1778-6543","position":9,"is_corresponding":false},{"id":142695,"name":"Dengke K. Ma","orcid":"0000-0002-5619-7485","position":10,"is_corresponding":false},{"id":577093,"name":"Wei Jiang","orcid":"0000-0001-7615-0900","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:19:18.686170Z","pmid":"37546737","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}