{"doi":"10.1101/2023.07.23.550235","title":"Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation","abstract":"Glycolysis is a fundamental cellular process, yet its regulatory mechanisms remain incompletely understood. Here, we show that a subset of glucose transporter 1 (GLUT1/SLC2A1) co-endocytoses with platelet-derived growth factor (PDGF) receptor (PDGFR) upon PDGF-stimulation. Furthermore, multiple glycolytic enzymes localize to these endocytosed PDGFR/GLUT1-containing vesicles adjacent to mitochondria. Contrary to current models, which emphasize the importance of glucose transporters on the cell surface, we find that PDGF-stimulated glucose uptake depends on receptor/transporter endocytosis. Our results suggest that growth factors generate glucose-loaded endocytic vesicles that deliver glucose to the glycolytic machinery in proximity to mitochondria, and argue for a new layer of regulation for glycolytic control governed by cellular membrane dynamics.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":400187,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231337,"name":"Beatrix Ueberheide","orcid":"0000-0003-2512-0204","position":1,"is_corresponding":false},{"id":79354,"name":"Feng-Xia Liang","orcid":"0000-0003-0037-4590","position":2,"is_corresponding":false},{"id":238068,"name":"Benjamin G. Neel","orcid":"0000-0002-9589-585X","position":3,"is_corresponding":false},{"id":1176494,"name":"Ryuichi Sakai","orcid":"0000-0001-6833-1103","position":4,"is_corresponding":false},{"id":942275,"name":"Yoshiro Saito","orcid":"0000-0002-0559-5889","position":5,"is_corresponding":false},{"id":1176493,"name":"Ryouhei Tsutsumi","orcid":"0000-0002-1704-0362","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T01:20:00.023537Z","pmid":"37546742","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}