{"doi":"10.1101/2023.07.22.550032","title":"An mTOR/RNA pol I axis shapes chromatin architecture in response to fasting","abstract":"Abstract Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom. Yet, how it impacts on 3D genome organization is unknown. Here, we show that fasting induces a reversible and large-scale spatial reorganization of chromatin in C. elegans . This fasting-induced 3D genome reorganization requires inhibition of the nutrient-sensing mTOR pathway, a major regulator of ribosome biogenesis. Remarkably, loss of transcription by RNA Pol I, but not RNA Pol II nor Pol III, induces a similar 3D genome reorganization in fed animals, and prevents the restoration of the fed-state architecture upon restoring nutrients to fasted animals. Our work documents the first large-scale chromatin reorganization triggered by fasting and reveals that mTOR and RNA Pol I shape genome architecture in response to nutrients.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394854,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1169680,"name":"Francesco Padovani","orcid":"0000-0003-2540-8240","position":1,"is_corresponding":false},{"id":1170227,"name":"Francesca Binando","orcid":null,"position":2,"is_corresponding":false},{"id":1169681,"name":"Johanna Hornung","orcid":"0000-0001-6542-3985","position":3,"is_corresponding":false},{"id":993478,"name":"Qiuxia Zhao","orcid":"0000-0001-9981-268X","position":4,"is_corresponding":false},{"id":883621,"name":"Benjamin D. Towbin","orcid":"0000-0001-7046-1257","position":5,"is_corresponding":false},{"id":554327,"name":"Elif Sarinay Cenik","orcid":"0000-0001-8514-5505","position":6,"is_corresponding":false},{"id":392145,"name":"Nicholas Stroustrup","orcid":"0000-0001-9530-7301","position":7,"is_corresponding":false},{"id":557920,"name":"Kurt M. Schmoller","orcid":"0000-0001-5790-5204","position":8,"is_corresponding":false},{"id":1169682,"name":"Daphne S. Cabianca","orcid":"0000-0002-1834-7868","position":9,"is_corresponding":false},{"id":1170226,"name":"Nada Al-Refaie","orcid":null,"position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:19:18.686170Z","pmid":"37503059","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}