{"doi":"10.1101/2023.07.21.550013","title":"Non-additive genetic components contribute significantly to population-wide gene expression variation","abstract":"Summary Gene expression variation, an essential step between genomic variation and phenotypic landscape, is collectively controlled by local ( cis ) and distant ( trans ) regulatory changes. Nevertheless, how these regulatory elements differentially influence the heritability of expression traits remains unclear. Here, we bridge this gap by analyzing the transcriptomes of a large diallel panel consisting of 323 unique hybrids originated from genetically divergent yeast isolates. We estimated the broad- and narrow-sense heritability across 5,087 transcript abundance traits and showed that non-additive components account for 36% of the phenotypic variance on average. By comparing allelic expression ratios in the hybrid and the corresponding parental pair, we identified regulatory changes in 25% of all cases, with a majority acting in trans . We further showed that trans- regulation could underlie coordinated expression variation across highly connected genes, resulting in significantly higher non-additive variance and most likely in some of the missing heritability of gene expression traits. Highlights Diallel panel for dissecting genetic components underlying gene expression variation Non-additive components account for 36% of gene expression trait heritability Most cis- regulatory variation is buffered by additional trans -acting variants Genes under trans- regulation show high non-additive variance and functional coherence","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":396918,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1107314,"name":"Gauthier Brach","orcid":null,"position":1,"is_corresponding":false},{"id":564855,"name":"Joseph Schacherer","orcid":"0000-0002-6606-6884","position":2,"is_corresponding":false},{"id":307111,"name":"Jing Hou","orcid":"0000-0003-2940-9670","position":3,"is_corresponding":false},{"id":564853,"name":"Andreas Tsouris","orcid":"0000-0002-5375-0660","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:19:35.497854Z","pmid":"37546809","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}