{"doi":"10.1101/2023.07.03.547520","title":"LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus","abstract":"Abstract Adipocyte-derived leptin enters the brain to exert its anorexigenic action, yet its transport mechanism is poorly understood. Here we report that LRP1 (low-density lipoprotein receptor-related protein-1) mediates the transport of leptin across the blood-CSF barrier in Foxj1 expressing cells highly enriched at the choroid plexus (ChP), coupled with the short-form leptin receptor, and LRP1 deletion from ependymocytes and ChP cells leads to leptin resistance and hyperphagia, causing obesity. Thus, LRP1 in epithelial cells is a principal regulator of leptin transport in the brain.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394796,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":827884,"name":"Won‐Mo Yang","orcid":"0000-0001-6742-720X","position":1,"is_corresponding":false},{"id":497846,"name":"Mincheol Kang","orcid":"0009-0005-2039-5163","position":2,"is_corresponding":false},{"id":1169341,"name":"Kellen Cristina da Cruz Rodrigues","orcid":"0000-0002-1714-1825","position":3,"is_corresponding":false},{"id":993350,"name":"A. Aydoğan","orcid":"0000-0003-2504-8150","position":4,"is_corresponding":false},{"id":298009,"name":"Ji A Seo","orcid":"0000-0002-1927-2618","position":5,"is_corresponding":false},{"id":1169342,"name":"Natália Ferreira Mendes","orcid":"0000-0001-9032-1411","position":6,"is_corresponding":false},{"id":298019,"name":"Min‐Seon Kim","orcid":"0000-0002-4881-0390","position":7,"is_corresponding":false},{"id":1169343,"name":"Fatima Ezzahra Timzoura","orcid":"0000-0002-0499-9785","position":8,"is_corresponding":false},{"id":106526,"name":"Michael J. Holtzman","orcid":"0000-0001-8750-3716","position":9,"is_corresponding":false},{"id":35236,"name":"Maria K. Lehtinen","orcid":"0000-0002-7243-2967","position":10,"is_corresponding":false},{"id":157966,"name":"Vincent Prévot","orcid":"0000-0001-7185-3615","position":11,"is_corresponding":false},{"id":298024,"name":"Young‐Bum Kim","orcid":"0000-0001-9471-6330","position":12,"is_corresponding":false},{"id":298015,"name":"Aykut Göktürk Üner","orcid":"0000-0002-9242-8279","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T01:19:14.590635Z","pmid":"37461530","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}