{"doi":"10.1101/2023.06.19.545593","title":"Regional pulmonary perfusion, blood volume, and their relationship change during early ARDS in an experimental study","abstract":"Abstract Regional pulmonary perfusion (Q) has been investigated using blood volume (F b ) imaging as an easier-to-measure surrogate. However, it is unclear if changing pulmonary conditions could affect their relationship. We hypothesized that vascular changes in early acute respiratory distress syndrome (ARDS) affect Q and F b differently. Five sheep were anesthetized and received protective mechanical ventilation for 20 hours while endotoxin was continuously infused. Using dynamic 18 F-FDG and 13 NN Positron Emission Tomography (PET), regional F b and Q were analysed in 30 regions of interest (ROIs) and normalized by tissue content (F bn and Q n , respectively). After 20 hours, the animals’ lung injury showed characteristics of early ARDS, including gas exchange and lung mechanics. PET images of F bn and Q n showed substantial differences between baseline and lung injury. Lung injury caused a significant change in the F bn -Q n relationship compared to baseline (p<0.001). The best models at baseline and lung injury were F bn =0.32+0.690Q n and F bn =1.684Q n –0.538Q n 2 , respectively. Early ARDS changed the relationship between F b and Q from linear to curvilinear. Effects of endotoxin exposure on the vasoactive blood flow regulation were most likely the key factor for this change limiting the quantitative accuracy of F b imaging as a surrogate for regional Q.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":408802,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":426841,"name":"Gabriel Ribeiro","orcid":"0000-0001-5982-8863","position":1,"is_corresponding":false},{"id":535486,"name":"Nicolas de Prost","orcid":"0000-0002-4833-4320","position":2,"is_corresponding":false},{"id":535487,"name":"Mauro R. Tucci","orcid":"0000-0001-9323-3222","position":3,"is_corresponding":false},{"id":535489,"name":"Tyler J. Wellman","orcid":"0009-0003-0912-9572","position":4,"is_corresponding":false},{"id":306996,"name":"Marcos F. Vidal Melo","orcid":"0000-0002-4901-4185","position":5,"is_corresponding":false},{"id":426842,"name":"Tilo Winkler","orcid":"0000-0002-7276-5550","position":6,"is_corresponding":false},{"id":1188380,"name":"Arnoldo Santos","orcid":"0000-0003-4797-9677","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:21:22.368387Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}